DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and sad

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_416042.2	Gene:	sad / 947440	ECOCYCID:	G6811	Length:	462	Species:	Escherichia coli

Alignment Length:	473	Identity:	141/473 - (29%)
Similarity:	219/473 - (46%)	Gaps:	46/473 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 TINPTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLA 123
            :|||.|.|.::.:..|..:||:.|:|.|...|:   .||..:...|...|..:...:......:|
E. coli    11 SINPATGEQLSVLPWAGADDIENALQLAAAGFR---DWRETNIDYRAEKLRDIGKALRARSEEMA 72

  Fly   124 SLETLDNGKPYS-----MSYNVDL---------------PTAIKNLRYFAGWADKNHGKTIPMDG 168
            .:.|.:.|||.:     ::.:.:|               ||.::|.:
E. coli    73 QMITREMGKPINQARAEVAKSANLCDWYAEHGPAMLKAEPTLVENQQ------------------ 119

  Fly   169 DFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTALYIAQLVKEAGF 233
               ....:.|:|....|:|||||:..:.....|.:..||..:||.|......|..|||:.|:||.
E. coli   120 ---AVIEYRPLGTILAIMPWNFPLWQVMRGAVPIILAGNGYLLKHAPNVMGCAQLIAQVFKDAGI 181

  Fly   234 PEGVVNVVPGFGTAGAALANHCDVDKVAFTGSTDVGKLIQLASGNTNLKRVTLELGGKSPNIILS 298
            |:||...:.......:.:.....:..|..|||...|..|...:| ..||:..|||||..|.|:|:
E. coli   182 PQGVYGWLNADNDGVSQMIKDSRIAAVTVTGSVRAGAAIGAQAG-AALKKCVLELGGSDPFIVLN 245

  Fly   299 DTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVGNPFDLNTEQGPQ 363
            |.|::.||:.|..|.:.|.||.|.|..|..:|:.|...|.||....|....:|:|.|.....||.
E. coli   246 DADLELAVKAAVAGRYQNTGQVCAAAKRFIIEEGIASAFTERFVAAAAALKMGDPRDEENALGPM 310

  Fly   364 VNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTIAREEIFGPVQQLI 428
            ...:..:::...::....|||:|:.||.:..|...|: .|||.|:|..:||..|||:||||..:.
E. coli   311 ARFDLRDELHHQVEKTLAQGARLLLGGEKMAGAGNYY-PPTVLANVTPEMTAFREEMFGPVAAIT 374

  Fly   429 RFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLAAQAPFGGYKMSGH 493
            ..|..:..:|.||:||:||:|.:||.|..:|..:...|..|.|::|.|....|:..|||.|.||.
E. coli   375 IAKDAEHALELANDSEFGLSATIFTTDETQARQMAARLECGGVFINGYCASDARVAFGGVKKSGF 439

  Fly   494 GRENGEYALSNYTEVKSV 511
            |||...:.|..:..:::|
E. coli   440 GRELSHFGLHEFCNIQTV 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	141/473 (30%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	141/473 (30%)
sad	NP_416042.2	PRK13968	1..462	CDD:184426	141/473 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
	2	1.810