DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and betB

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_414846.1	Gene:	betB / 947376	ECOCYCID:	EG10110	Length:	490	Species:	Escherichia coli

Alignment Length:	483	Identity:	211/483 - (43%)
Similarity:	292/483 - (60%)	Gaps:	7/483 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERGR 106
            ::|:..:..:.||:.||||||....|:|.:|.|.:||:|.||::|:...|:   |..|.|.||.|
E. coli     9 LYIHGGYTSATSGRTFETINPANGNVLATVQAAGREDVDRAVKSAQQGQKI---WASMTAMERSR 70

  Fly   107 LLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTIPMDGDFF 171
            :|.|..|::......||.|||||.||.||.:..||:.|....|.|:||......|..||:....|
E. coli    71 ILRRAVDILRERNDELAKLETLDTGKAYSETSTVDIVTGADVLEYYAGLIPALEGSQIPLRETSF 135

  Fly   172 TYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTALYIAQLVKEAGFPEG 236
            .|||.||:||...|..||:||.:..||..||||.||.::.||:|.|.||||.:|::..|||.|:|
E. coli   136 VYTRREPLGVVAGIGAWNYPIQIALWKSAPALAAGNAMIFKPSEVTPLTALKLAEIYSEAGLPDG 200

  Fly   237 VVNVVPGFGT-AGAALANHCDVDKVAFTGSTDVGKLIQLASGNTNLKRVTLELGGKSPNIILSDT 300
            |.||:||.|. .|..|..|..:.||:|||....||.:...|..::||.||:|||||||.|:..|.
E. coli   201 VFNVLPGVGAETGQYLTEHPGIAKVSFTGGVASGKKVMANSAASSLKEVTMELGGKSPLIVFDDA 265

  Fly   301 DMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVGNPFDLNTEQGPQVN 365
            |:|.|.:.|....||:.||.|..|:|.||..|....|.::...|.::...|:.||..|..||.|:
E. coli   266 DLDLAADIAMMANFFSSGQVCTNGTRVFVPAKCKAAFEQKILARVERIRAGDVFDPQTNFGPLVS 330

  Fly   366 EEQMEKILGMIKTGKKQGAKLVAGGS--RPEGLP-GYFVQPTVFADVQDDMTIAREEIFGPVQQL 427
            ....:.:|..|..||::||:::.||.  :.:|.. |.:|.||||.|..|||||.||||||||..:
E. coli   331 FPHRDNVLRYIAKGKEEGARVLCGGDVLKGDGFDNGAWVAPTVFTDCSDDMTIVREEIFGPVMSI 395

  Fly   428 IRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLAAQAPFGGYKMSG 492
            :.::..||||.|||:::|||||.:.|.||::|:.::..|.||..|:||:....|:.|.||||.||
E. coli   396 LTYESEDEVIRRANDTDYGLAAGIVTADLNRAHRVIHQLEAGICWINTWGESPAEMPVGGYKHSG 460

  Fly   493 HGRENGEYALSNYTEVKSVIVKVAQKNS 520
            .|||||...|.:||:|||:.|::|:..|
E. coli   461 IGRENGVMTLQSYTQVKSIQVEMAKFQS 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	208/473 (44%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	208/475 (44%)
betB	NP_414846.1	PRK13252	1..490	CDD:183918	211/483 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	389	1.000	Domainoid score	I16
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	1	1.000	-	-
Inparanoid	1	1.050	388	1.000	Inparanoid score	I51
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	1	1.000	-	-		otm51435
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
	7	6.860