DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and paaZ

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_415905.1	Gene:	paaZ / 945954	ECOCYCID:	G6708	Length:	681	Species:	Escherichia coli

Alignment Length:	515	Identity:	131/515 - (25%)
Similarity:	203/515 - (39%)	Gaps:	56/515 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 FINNEWH--KSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARN-AFKLGSP-WRRMDASE 103
            |::..|.  :.:|..|...|   :.|.:.|:   ..|.:|:|  |||. |.:.|:| .|.|...|
E. coli     7 FLSGTWQSGRGRSRLIHHAI---SGEALWEV---TSEGLDMA--AARQFAIEKGAPALRAMTFIE 63

  Fly   104 RGRLLYRLAD--LMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWADKN------- 159
            |..:|..:|.  |.|:::.|..|.:|   |...:.|: ||:...|..|..:|....:.
E. coli    64 RAAMLKAVAKHLLSEKERFYALSAQT---GATRADSW-VDIEGGIGTLFTYASLGSRELPDDTLW 124

  Fly   160 -HGKTIPMDGDFFTYTRH---EPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTS-L 219
             ..:.||:..:.....||   ...||...|..:|||...|..||.|....|...::|||..|: |
E. coli   125 PEDELIPLSKEGGFAARHLLTSKSGVAVHINAFNFPCWGMLEKLAPTWLGGMPAIIKPATATAQL 189

  Fly   220 TALYIAQLVKEAGFPEGVVNVVPGFGTAGAALANHCD-VDKVAFTGSTDVGKLIQLASGNTNLKR 283
            |...:..:|.....|||.::::  .|:|| .|.:|.| .|.|.||||...|::::: ..|...|.
E. coli   190 TQAMVKSIVDSGLVPEGAISLI--CGSAG-DLLDHLDSQDVVTFTGSAATGQMLRV-QPNIVAKS 250

  Fly   284 VTLELGGKSPN-IILSDTDMDYAVETAHFGLFF---------NMGQCCCAGSRTFVEDKIYDEFV 338
            :...:...|.| .:|.:   |...:...|.||.         ..||.|.|..|..|...:.:...
E. coli   251 IPFTMEADSLNCCVLGE---DVTPDQPEFALFIREVVREMTTKAGQKCTAIRRIIVPQALVNAVS 312

  Fly   339 ERSAERAKKRTVGNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQP 403
            :....|.:|..||:|.....:.|..||.||...:...:......|.::..||.......|.|..|
E. coli   313 DALVARLQKVVVGDPAQEGVKMGALVNAEQRADVQEKVNILLAAGCEIRLGGQADLSAAGAFFPP 377

  Fly   404 TVFADVQDDMT--IAREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGL 466
            |:....|.|.|  :...|.||||..|:..:.....::.|......||..:.|.|...|...:...
E. coli   378 TLLYCPQPDETPAVHATEAFGPVATLMPAQNQRHALQLACAGGGSLAGTLVTADPQIARQFIADA 442

  Fly   467 RAGTVWVNTYNVLAAQ------APFGGYKMSGHGRENGEYALSNYTEVKSVIVKVAQKNS 520
            ......:...|..:|:      :|.......|.||..|...|.....||..:.:.|.:.|
E. coli   443 ARTHGRIQILNEESAKESTGHGSPLPQLVHGGPGRAGGGEELGGLRAVKHYMQRTAVQGS 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	129/505 (26%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	129/507 (25%)
paaZ	NP_415905.1	PRK11563	1..674	CDD:236931	131/515 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
	2	1.810