DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and patD

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_415961.1	Gene:	patD / 945876	ECOCYCID:	G6755	Length:	474	Species:	Escherichia coli

Alignment Length:	485	Identity:	180/485 - (37%)
Similarity:	276/485 - (56%)	Gaps:	23/485 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 ILYTGVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDA 101
            :|..|..::.|..|.      ...||.|.:|:.||..|..|.:|.||:||..||   :.|.:...
E. coli     5 LLINGELVSGEGEKQ------PVYNPATGDVLLEIAEASAEQVDAAVRAADAAF---AEWGQTTP 60

  Fly   102 SERGRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTIPM 166
            ..|...|.:|||::|.:....|.||:.:.|||...::|.::|..:...|:|||.|...:|...
E. coli    61 KVRAECLLKLADVIEENGQVFAELESRNCGKPLHSAFNDEIPAIVDVFRFFAGAARCLNGLAA-- 123

  Fly   167 DGDFF----TYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTALYIAQL 227
             |::.    :..|.:|:||...|.|||:|::|.||||.||||.||.:||||:|.|.||||.:|:|
E. coli   124 -GEYLEGHTSMIRRDPLGVVASIAPWNYPLMMAAWKLAPALAAGNCVVLKPSEITPLTALKLAEL 187

  Fly   228 VKEAGFPEGVVNVVPGFG-TAGAALANHCDVDKVAFTGSTDVGKLIQLASGNTNLKRVTLELGGK 291
            .|:. ||.||:|::.|.| |.|..|..|..|..|:.|||...|:.| ::...:::||..:|||||
E. coli   188 AKDI-FPAGVINILFGRGKTVGDPLTGHPKVRMVSLTGSIATGEHI-ISHTASSIKRTHMELGGK 250

  Fly   292 SPNIILSDTDMDYAVETAH-FGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVGNPFD 355
            :|.|:..|.|::..||... || ::|.||.|.|..|.:.:..|||..||:..........|.|.|
E. coli   251 APVIVFDDADIEAVVEGVRTFG-YYNAGQDCTAACRIYAQKGIYDTLVEKLGAAVATLKSGAPDD 314

  Fly   356 LNTEQGPQVNEEQMEKILGMIKTGKKQG-AKLVAGGSRPEGLPGYFVQPTVFADVQDDMTIAREE 419
            .:||.||..:...:|::...::..|..| .|::.||.:.:| .||:..||:.|....|..|.::|
E. coli   315 ESTELGPLSSLAHLERVGKAVEEAKATGHIKVITGGEKRKG-NGYYYAPTLLAGALQDDAIVQKE 378

  Fly   420 IFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLAAQAP 484
            :||||..:..|...::|:..||:|:||||::|:|||:.:|:.:...|:.|..||||:.:|.::.|
E. coli   379 VFGPVVSVTPFDNEEQVVNWANDSQYGLASSVWTKDVGRAHRVSARLQYGCTWVNTHFMLVSEMP 443

  Fly   485 FGGYKMSGHGRENGEYALSNYTEVKSVIVK 514
            .||.|:||:|::...|.|.:||.|:.|:||
E. coli   444 HGGQKLSGYGKDMSLYGLEDYTVVRHVMVK 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	177/481 (37%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	178/483 (37%)
patD	NP_415961.1	ABALDH	2..473	CDD:132417	178/483 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
	2	1.810