DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and aldA

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_415933.1	Gene:	aldA / 945672	ECOCYCID:	EG10035	Length:	479	Species:	Escherichia coli

Alignment Length:	480	Identity:	163/480 - (33%)
Similarity:	259/480 - (53%)	Gaps:	17/480 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSP-WRRMDASERG 105
            ::|:.::...:.....:.:||.|..||:.|.....||...|:.||..|    .| |..:.|.||.
E. coli     9 MYIDGQFVTWRGDAWIDVVNPATEAVISRIPDGQAEDARKAIDAAERA----QPEWEALPAIERA 69

  Fly   106 RLLYRL-ADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTIPMD-- 167
            ..|.:: |.:.||.. .:::|...:.||...:: .|::......:.|.|.||.:..|:.|..|
E. coli    70 SWLRKISAGIRERAS-EISALIVEEGGKIQQLA-EVEVAFTADYIDYMAEWARRYEGEIIQSDRP 132

  Fly   168 -GDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTALYIAQLVKEA 231
             .:...:.|  .:||...|:|||||..::|.|:.|||.||||||:||:|.|...|:..|::|.|.
E. coli   133 GENILLFKR--ALGVTTGILPWNFPFFLIARKMAPALLTGNTIVIKPSEFTPNNAIAFAKIVDEI 195

  Fly   232 GFPEGVVNVVPGFG-TAGAALANHCDVDKVAFTGSTDVGKLIQLASGNTNLKRVTLELGGKSPNI 295
            |.|.||.|:|.|.| |.|..||.:..|..|:.|||...|:.| :|:...|:.:|.||||||:|.|
E. coli   196 GLPRGVFNLVLGRGETVGQELAGNPKVAMVSMTGSVSAGEKI-MATAAKNITKVCLELGGKAPAI 259

  Fly   296 ILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVGNPFDLN-TE 359
            ::.|.|::.||:........|.||.|....|.:|:..|||:||.|..|..:....|||.:.| ..
E. coli   260 VMDDADLELAVKAIVDSRVINSGQVCNCAERVYVQKGIYDQFVNRLGEAMQAVQFGNPAERNDIA 324

  Fly   360 QGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTIAREEIFGPV 424
            .||.:|...:|::...:....::||::..||...|| .||:..||:..||:.:|:|..||.||||
E. coli   325 MGPLINAAALERVEQKVARAVEEGARVAFGGKAVEG-KGYYYPPTLLLDVRQEMSIMHEETFGPV 388

  Fly   425 QQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLAAQAPFGGYK 489
            ..::.|..|::.|..||:|:|||.::::|::|:.|...:.||:.|..::|..|..|.|....|::
E. coli   389 LPVVAFDTLEDAISMANDSDYGLTSSIYTQNLNVAMKAIKGLKFGETYINRENFEAMQGFHAGWR 453

  Fly   490 MSGHGRENGEYALSNYTEVKSVIVK 514
            .||.|..:|::.|..|.:.:.|.::
E. coli   454 KSGIGGADGKHGLHEYLQTQVVYLQ 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	162/476 (34%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	163/478 (34%)
aldA	NP_415933.1	PRK10090	72..479	CDD:182233	145/413 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	1	1.000	-	-
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
	3	2.810