Protein Alignment Aldh and ALDH1A2

DIOPT Version :9

• Sequence 1: NP_001260290.1
• Gene: Aldh / 34256
• FlyBaseID: FBgn0012036
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_003879.2
• Gene: ALDH1A2 / 8854
• HGNCID: 15472
• Length: 518
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 323/503 - (64%)
• Similarity: 406/503 - (80%)
• Gaps: 2/503 - (0%)

  Fly    19 AAAVANYSSLPQPQTTPDILYTGVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAV 83
            ||.:|:...||.|....:|.||.:||||||..|:||::|...||.|.|.:.|:|.|||.|||.||
Human    17 AALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAV 81

  Fly    84 QAARNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKN 148
            ||||.||.|||.|||||||||||||.:||||:|||:..||::|:|:.|||:..::.|||...||.
Human    82 QAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKT 146

  Fly   149 LRYFAGWADKNHGKTIPMDGDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKP 213
            .||:||||||.||.|||:|||:||:|||||:||||||||||||:||.|||:.|||..|||:|:||
Human   147 FRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKP 211

  Fly   214 AEQTSLTALYIAQLVKEAGFPEGVVNVVPGFG-TAGAALANHCDVDKVAFTGSTDVGKLIQLASG 277
            ||||.|:|||:..|:||||||.||:|::||:| |||||:|:|..:||:||||||:||||||.|:|
Human   212 AEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAG 276

  Fly   278 NTNLKRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSA 342
            .:|||||||||||||||||.:|.|:|||||.||.|:|||.||||.||||.|||:.||:|||.||.
Human   277 RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSV 341

  Fly   343 ERAKKRTVGNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPTVFA 407
            ||||:|.||:|||..||||||::::|..|||.:|::|..:||||..|| :..|..|:|::||||:
Human   342 ERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGG-KGLGRKGFFIEPTVFS 405

  Fly   408 DVQDDMTIAREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVW 472
            :|.|||.||:||||||||:::|||.:||||||||||::||.|||||.|::||..:...::|||||
Human   406 NVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVW 470

  Fly   473 VNTYNVLAAQAPFGGYKMSGHGRENGEYALSNYTEVKSVIVKVAQKNS 520
            :|.||.|.||:||||:||||:|||.||:.|..|:|||:|.||:.||||
Human   471 INCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	316/493 (64%)
		ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	311/480 (65%)
ALDH1A2	NP_003879.2	ALDH_F1AB_F2_RALDH1	32..512	CDD:143459	311/480 (65%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53964
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100163
Panther	1	1.100	-	-	O	PTHR11699
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X158
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.830