DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and ALDH4A1

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_003739.2	Gene:	ALDH4A1 / 8659	HGNCID:	406	Length:	563	Species:	Homo sapiens

Alignment Length:	514	Identity:	124/514 - (24%)
Similarity:	222/514 - (43%)	Gaps:	65/514 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 TPDILYTGVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRR 98
            |.|:.|. |...|..||                 :|:...|||..::.|::||..|.|   .|..
Human    75 TSDVQYQ-VSPFNHGHK-----------------VAKFCYADKSLLNKAIEAALAARK---EWDL 118

  Fly    99 MDASERGRLLYRLADLM---ERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWADKNH 160
            ...::|.::..:.||::   .|.::...::  :..||....:........|...|:.|.:|.:..
Human   119 KPIADRAQIFLKAADMLSGPRRAEILAKTM--VGQGKTVIQAEIDAAAELIDFFRFNAKYAVELE 181

  Fly   161 GK---TIPMDGDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTAL 222
            |:   ::|...:...|...|  |....|.|:||..:.......||| .||.::.||::...|.:.
Human   182 GQQPISVPPSTNSTVYRGLE--GFVAAISPFNFTAIGGNLAGAPAL-MGNVVLWKPSDTAMLASY 243

  Fly   223 YIAQLVKEAGFPEGVVNVVPG----FGTAGAALANHCDVDKVAFTGSTDVGKLI--QLASGNTNL 281
            .:.::::|||.|..::..||.    ||....:..:.|.::   ||||....|.:  |:|.   ||
Human   244 AVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGIN---FTGSVPTFKHLWKQVAQ---NL 302

  Fly   282 ------KRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVER 340
                  .|:..|.|||:.:.:....|::..|.......|...||.|.|.||.:|...::.:...|
Human   303 DRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGR 367

  Fly   341 SAERAKKRTVGNPF-DLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPT 404
            ..|...:..||:|. |..|.....::.:...:|...::..:...:..:..|.:.:...||||:|.
Human   368 LLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPC 432

  Fly   405 VFADVQDDMTIAREEIFGPVQQLI-----RFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVG 464
            :.........|.:|||||||..:.     ::|:..::::  :.:.|||..|||::|.|.......
Human   433 IVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATK 495

  Fly   465 GLR--AGTVWVNTYNV--LAAQAPFGGYKMSG-HGRENGEYALSNYTEVKSVIVKVAQK 518
            .||  ||..::|..:.  :..|.||||.:.|| :.:..|.:.:..:|..:  ::|...|
Human   496 VLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQ--VIKETHK 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	122/506 (24%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	122/508 (24%)
ALDH4A1	NP_003739.2	ALDH_F4-17_P5CDH	32..553	CDD:143441	124/514 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810