DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and MSC7

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_011904.1	Gene:	MSC7 / 856434	SGDID:	S000001081	Length:	644	Species:	Saccharomyces cerevisiae

Alignment Length:	556	Identity:	154/556 - (27%)
Similarity:	250/556 - (44%)	Gaps:	75/556 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLRVLKTGALLRSQAK--NFAAAVANYSSLPQPQTTPDILYTGVFINNEW--HKSKSGKIF--ET 59
            :::::.|.|...|..|  .|        |||.|:..          .|.|  .:|.|..|:  |.
Yeast    62 LVKIISTPAKCSSSYKPVKF--------SLPAPEAA----------QNNWKGKRSVSTNIWNPEE 108

  Fly    60 IN------PTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERGRLLYRLADLMERD 118
            .|      |.|.:.:.......:.|||   :....|.|..|.|...|.|.|.|:|..|.|.:..:
Yeast   109 PNFIQCHCPATGQYLGSFPSKTEADID---EMVSKAGKAQSTWGNSDFSRRLRVLASLHDYILNN 170

  Fly   119 QVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTI------PMDGDFF------ 171
            |..:|.:...|:||....:...::...::.::    |..| ||:..      |...:||
Yeast   171 QDLIARVACRDSGKTMLDASMGEILVTLEKIQ----WTIK-HGQRALQPSRRPGPTNFFMKWYKG 230

  Fly   172 TYTRHEPVGVCGQIIPWNFPILMMAWKLGP---ALATGNTIVLKPAEQTSLTALYIAQLVKEA-- 231
            ...|:||:||...|:.||:|...:   |||   ||.|||.||:|.:||...::.:..:|:::.
Yeast   231 AEIRYEPLGVISSIVSWNYPFHNL---LGPIIAALFTGNAIVVKCSEQVVWSSEFFVELIRKCLE 292

  Fly   232 ---GFPEGV--VNVVPGFGTAGAA--LANHCDVDKVAFTGSTDVGKLIQLASGNTNLKRVTLELG 289
               ..|:.|  ...:|......:|  ..:|.....:.|.||..|...| |.....:|..|.:|||
Yeast   293 ACDEDPDLVQLCYCLPPTENDDSANYFTSHPGFKHITFIGSQPVAHYI-LKCAAKSLTPVVVELG 356

  Fly   290 GKSPNIIL-SDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVGNP 353
            ||...|:| |..::|........|.|.:.||.|....|..|..:.||:.|:...:|.....:...
Yeast   357 GKDAFIVLDSAKNLDALSSIIMRGTFQSSGQNCIGIERVIVSKENYDDLVKILNDRMTANPLRQG 421

  Fly   354 FDL----NTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSR---PEGLPGYFVQPTVFADVQD 411
            .|:    |.:.|..:::.:.:::..::|....:||:|:.||||   |:...|::.|||:..||..
Yeast   422 SDIDHLENVDMGAMISDNRFDELEALVKDAVAKGARLLQGGSRFKHPKYPQGHYFQPTLLVDVTP 486

  Fly   412 DMTIAREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTY 476
            :|.||:.|:|||:..:::.|..|..::.||::.:||..:||..|:.:.||:...|:.|.|.:|.:
Yeast   487 EMKIAQNEVFGPILVMMKAKNTDHCVQLANSAPFGLGGSVFGADIKECNYVANSLQTGNVAINDF 551

  Fly   477 -NVLAAQAPFGGYKMSGHGRENGEYALSNYTEVKSV 511
             .....|.||||...||:|:..||..|......|||
Yeast   552 ATFYVCQLPFGGINGSGYGKFGGEEGLLGLCNAKSV 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	153/548 (28%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	145/521 (28%)
MSC7	NP_011904.1	ALDH_F15-22	115..590	CDD:143416	138/485 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S334
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.760