DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and ALD6

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_015264.1	Gene:	ALD6 / 856044	SGDID:	S000005982	Length:	500	Species:	Saccharomyces cerevisiae

Alignment Length:	480	Identity:	226/480 - (47%)
Similarity:	313/480 - (65%)	Gaps:	9/480 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 TGVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASER 104
            ||:||||::.|::.||.:...:|:|...:.|:..|..||::.|::.|..||. .:.|...|..||
Yeast    26 TGLFINNKFMKAQDGKTYPVEDPSTENTVCEVSSATTEDVEYAIECADRAFH-DTEWATQDPRER 89

  Fly   105 GRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTIPMDGD 169
            ||||.:|||.:|.....::|:|.|||||..:::.. |:..||..||..|.:|||.:|:||.....
Yeast    90 GRLLSKLADELESQIDLVSSIEALDNGKTLALARG-DVTIAINCLRDAAAYADKVNGRTINTGDG 153

  Fly   170 FFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTALYIAQLVKEAGFP 234
            :..:|..||:|||||||||||||:|:|||:.||||.||..:||||..|.|.|||.|.|.|:.|.|
Yeast   154 YMNFTTLEPIGVCGQIIPWNFPIMMLAWKIAPALAMGNVCILKPAAVTPLNALYFASLCKKVGIP 218

  Fly   235 EGVVNVVPGFG-TAGAALANHCDVDKVAFTGSTDVGKLIQLASGNTNLKRVTLELGGKSPNIILS 298
            .||||:|||.| |.||||.|...:.|:||||||:|||.:.:.|..:|||::||||||||.:::..
Yeast   219 AGVVNIVPGPGRTVGAALTNDPRIRKLAFTGSTEVGKSVAVDSSESNLKKITLELGGKSAHLVFD 283

  Fly   299 DTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRT---VGNPFDLNTEQ 360
            |.::...:.....|:|.|.||.|.:|||.:|::.||||.:  :|.:|...|   ||||||....|
Yeast   284 DANIKKTLPNLVNGIFKNAGQICSSGSRIYVQEGIYDELL--AAFKAYLETEIKVGNPFDKANFQ 346

  Fly   361 GPQVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTIAREEIFGPVQ 425
            |...|.:|.:.|:..|..|||:|||::.||.: .|..|||::||||.||.:||.|.:|||||||.
Yeast   347 GAITNRQQFDTIMNYIDIGKKEGAKILTGGEK-VGDKGYFIRPTVFYDVNEDMRIVKEEIFGPVV 410

  Fly   426 QLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLAAQAPFGGYKM 490
            .:.:||.|:|.:|.||:||:||.:.:.|:.|.....:...|:|||||:||||...::.||||.|.
Yeast   411 TVAKFKTLEEGVEMANSSEFGLGSGIETESLSTGLKVAKMLKAGTVWINTYNDFDSRVPFGGVKQ 475

  Fly   491 SGHGRENGEYALSNYTEVKSVIVKV 515
            ||:|||.||.....|||||:|.:|:
Yeast   476 SGYGREMGEEVYHAYTEVKAVRIKL 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	224/475 (47%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	225/477 (47%)
ALD6	NP_015264.1	ALDH_F1-2_Ald2-like	23..498	CDD:143410	225/476 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344465
Domainoid	1	1.000	453	1.000	Domainoid score	I61
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	472	1.000	Inparanoid score	I229
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53964
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	1	1.000	-	-		mtm9192
orthoMCL	1	0.900	-	-		OOG6_100163
Panther	1	1.100	-	-	O	PTHR11699
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X158
TreeFam	0	0.000	Not matched by this tool.
	11	10.800