DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and UGA2

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_009560.1	Gene:	UGA2 / 852291	SGDID:	S000000210	Length:	497	Species:	Saccharomyces cerevisiae

Alignment Length:	492	Identity:	169/492 - (34%)
Similarity:	260/492 - (52%)	Gaps:	28/492 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PDILYTGVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRM 99
            |::.....:|:.:|.|. :.::||.::|.:.|:||.:.......::.|:..|...||   .::..
Yeast    14 PNLFRESGYIDGKWVKG-TDEVFEVVDPASGEIIARVPEQPVSVVEEAIDVAYETFK---TYKNT 74

  Fly   100 DASERGRLLYRLADLMERDQVYLASLETLDNGK---------PYSMSYNVDLPTAIKNLRYFAGW 155
            ...||.:.|..:.:||..:...||::.||:|||         .|:.||          ..::|..
Yeast    75 TPRERAKWLRNMYNLMLENLDDLATIITLENGKALGEAKGEIKYAASY----------FEWYAEE 129

  Fly   156 ADKNHGKTI-PMDGDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSL 219
            |.:.:|.|| |::.....:|..:||||||.|.|||||..|:..|...|||.|.|:|:||..||.|
Yeast   130 APRLYGATIQPLNPHNRVFTIRQPVGVCGIICPWNFPSAMITRKAAAALAVGCTVVIKPDSQTPL 194

  Fly   220 TALYIAQLVKEAGFPEGVVNVVPGFGTA---GAALANHCDVDKVAFTGSTDVGKLIQLASGNTNL 281
            :||.:|.|.::||||:|..||:......   |..|.....|.||.|||||:|||::...|.:| |
Yeast   195 SALAMAYLAEKAGFPKGSFNVILSHANTPKLGKTLCESPKVKKVTFTGSTNVGKILMKQSSST-L 258

  Fly   282 KRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAK 346
            |:::.||||.:|.|:..|.|:|.|:|.|....|..:||.|...:|.:|...|.|:|.:..|||.|
Yeast   259 KKLSFELGGNAPFIVFEDADLDQALEQAMACKFRGLGQTCVCANRLYVHSSIIDKFAKLLAERVK 323

  Fly   347 KRTVGNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPTVFADVQD 411
            |..:|:..|..|..|..:|...:||:....:....:|||:|..|.|...|...|..|.:.:.|..
Yeast   324 KFVIGHGLDPKTTHGCVINSSAIEKVERHKQDAIDKGAKVVLEGGRLTELGPNFYAPVILSHVPS 388

  Fly   412 DMTIAREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTY 476
            ...:::||.|||:..:..|..::||:..||::|:||||.||:|:::....:...|..|.|..||.
Yeast   389 TAIVSKEETFGPLCPIFSFDTMEEVVGYANDTEFGLAAYVFSKNVNTLYTVSEALETGMVSCNTG 453

  Fly   477 NVLAAQAPFGGYKMSGHGRENGEYALSNYTEVKSVIV 513
            .......||||.|.||.|||...|.:.:||.:|::.:
Yeast   454 VFSDCSIPFGGVKESGFGREGSLYGIEDYTVLKTITI 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	169/489 (35%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	169/492 (34%)
UGA2	NP_009560.1	SSADH	37..486	CDD:188167	162/462 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810