DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and ALDH2C4

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_566749.1	Gene:	ALDH2C4 / 822042	AraportID:	AT3G24503	Length:	501	Species:	Arabidopsis thaliana

Alignment Length:	481	Identity:	252/481 - (52%)
Similarity:	337/481 - (70%)	Gaps:	4/481 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PDILYTGVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRM 99
            |:|.:|.:|||.::..:.|||.||||:|...||||.|...||||:|:||.|||.||..| ||.||
plant    15 PEIKFTKLFINGQFIDAASGKTFETIDPRNGEVIATIAEGDKEDVDLAVNAARYAFDHG-PWPRM 78

  Fly   100 DASERGRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTI 164
            ...||.:|:.:.|||:|.:...||.|:.:|.||.:.:....|:|....:.||.||.|||.||:|:
plant    79 TGFERAKLINKFADLIEENIEELAKLDAVDGGKLFQLGKYADIPATAGHFRYNAGAADKIHGETL 143

  Fly   165 PMD-GDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTALYIAQLV 228
            .|. ...|.||..||:||.|.|||||||.:|.|.|:.||:|.|.|:|:||||||||:||:.|.|.
plant   144 KMTRQSLFGYTLKEPIGVVGNIIPWNFPSIMFATKVAPAMAAGCTMVVKPAEQTSLSALFYAHLS 208

  Fly   229 KEAGFPEGVVNVVPGFG-TAGAALANHCDVDKVAFTGSTDVGKLIQLASGNTNLKRVTLELGGKS 292
            ||||.|:||:|:|.||| |||||:|:|.|||||:||||||||:.|..|:..:|||:|:|||||||
plant   209 KEAGIPDGVLNIVTGFGSTAGAAIASHMDVDKVSFTGSTDVGRKIMQAAAASNLKKVSLELGGKS 273

  Fly   293 PNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVGNPFDLN 357
            |.:|.:|.|:|.|.:.|..|.|:|.|:.|.|.||.||::.|||:.||:..|:||..|||:|||..
plant   274 PLLIFNDADIDKAADLALLGCFYNKGEICVASSRVFVQEGIYDKVVEKLVEKAKDWTVGDPFDST 338

  Fly   358 TEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTIAREEIFG 422
            ..|||||::.|.||||..|:.||.:||.|:.|| :..|..|||:|||:||||.:||.|.::||||
plant   339 ARQGPQVDKRQFEKILSYIEHGKNEGATLLTGG-KAIGDKGYFIQPTIFADVTEDMKIYQDEIFG 402

  Fly   423 PVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLAAQAPFGG 487
            ||..|::||.::|.|:.|||::|||||.:.::|:|..|.:...::||.:|||.|.......|:||
plant   403 PVMSLMKFKTVEEGIKCANNTKYGLAAGILSQDIDLINTVSRSIKAGIIWVNCYFGFDLDCPYGG 467

  Fly   488 YKMSGHGRENGEYALSNYTEVKSVIV 513
            |||||:.||:|..||.||.:.|||::
plant   468 YKMSGNCRESGMDALDNYLQTKSVVM 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	251/478 (53%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	252/481 (52%)
ALDH2C4	NP_566749.1	PLN02766	1..501	CDD:215410	252/481 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53964
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100163
Panther	1	1.100	-	-	O	PTHR11699
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X158
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.830