DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and ALDH22A1

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_974242.1	Gene:	ALDH22A1 / 819849	AraportID:	AT3G66658	Length:	596	Species:	Arabidopsis thaliana

Alignment Length:	529	Identity:	148/529 - (27%)
Similarity:	238/529 - (44%)	Gaps:	46/529 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 FAAAVANYSSLPQPQTTP-------DILYTG--------VFINNEWHKSKSGKIFETINPTTAEV 67
            ||.|:..:..:..|...|       |:|..|        ::|.......:|.|..:...|.|.:.
plant    12 FAYAICKFLLMLIPPNVPSIDVDASDVLAHGKDTEENSFIYIPPRGRSQQSDKKVQCYEPATMKY 76

  Fly    68 IAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDNGK 132
            :.........:::..|..:|.|.|   .|.:.....|.:.|..|...:...|..:..:.:.|.||
plant    77 LGYFPALSPTEVEERVTLSRKAQK---TWAQSSFKLRRQFLRILLKYIIEHQELICEVSSRDTGK 138

  Fly   133 PYSMSYNVDLPTAIKNLRYFAG----W---ADKNHGKTIPMDGDFFTYTRHE--PVGVCGQIIPW 188
            ....:...::.|..:.:.:...    |   ..::.|:.:     ....:|.|  |:||.|.|:||
plant   139 TMVDASLGEIMTTCEKITWLLSEGERWLKPESRSSGRAM-----LHKVSRVEFHPLGVIGAIVPW 198

  Fly   189 NFPILMMAWKLGPALATGNTIVLKPAEQTSLTALYIAQLVKEA----GFPEGVVNVVPGFGTAGA 249
            |:|...:...:..|:.:||.||:|.:|..|.:..:..::::.|    |.||.:|:|:.||...|.
plant   199 NYPFHNIFNPMLAAVFSGNGIVIKVSEHASWSGCFYFRIIQAALAAVGAPENLVDVITGFAETGE 263

  Fly   250 ALANHCDVDKVAFTGSTDVGKLIQLASGNTNLKRVTLELGGKSPNIILSDTDMDYAVETAHFGLF 314
            ||.:  .|||:.|.|||.|||:|...:..| |..||||||||...||..|.|:.:..:.|..|..
plant   264 ALVS--SVDKMIFVGSTAVGKMIMRNAAET-LTPVTLELGGKDAFIICEDADVSHVAQVAVRGTL 325

  Fly   315 FNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVGNPFDLNTEQGPQVNEEQMEKILGMIKTG 379
            .:.||.|....|.:|...||..|:.:..:..|..:.|.|.....:.|....:|..|.:..::...
plant   326 QSSGQNCAGAERFYVHKDIYTAFIGQVTKIVKSVSAGPPLTGRYDMGAICLQEHSEHLQSLVNDA 390

  Fly   380 KKQGAKLVAGGS----RPEGLPGYFVQPTVFADVQDDMTIAREEIFGPVQQLIRFKKLDEVIERA 440
            ..:||::...||    ..:.:..|| .|||..:|..:|.|.:||.|||:..:::|...:|||:.|
plant   391 LDKGAEIAVRGSFGHLGEDAVDQYF-PPTVLINVNHNMKIMKEEAFGPIMPIMQFSTDEEVIKLA 454

  Fly   441 NNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTY--NVLAAQAPFGGYKMSGHGRENGEYALS 503
            |:|.|.|..|||:....:|..|...::.|...:|.:  |.:....||||.|.||.||..|...|.
plant   455 NDSRYALGCAVFSGSKHRAKQIASQIQCGVAAINDFASNYMCQSLPFGGVKDSGFGRFAGIEGLR 519

  Fly   504 NYTEVKSVI 512
            ....||||:
plant   520 ACCLVKSVV 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	147/527 (28%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	144/513 (28%)
ALDH22A1	NP_974242.1	ALDH_F15-22	69..531	CDD:143416	137/472 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810