DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and ALDH5A1

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_733936.1	Gene:	ALDH5A1 / 7915	HGNCID:	408	Length:	548	Species:	Homo sapiens

Alignment Length:	518	Identity:	173/518 - (33%)
Similarity:	262/518 - (50%)	Gaps:	35/518 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SQAKNFAAAVANYSSLPQPQTTPDILYTGVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKE 77
            :|.:.:|..:|..|:.        :|.|..|:...|  ..:...|...:|.:...:..:......
Human    42 AQLRCYAGRLAGLSAA--------LLRTDSFVGGRW--LPAAATFPVQDPASGAALGMVADCGVR 96

  Fly    78 DIDIAVQAARNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDL 142
            :...||:||..||   ..||.:.|.||..||.:..:||.:::..||.:.|.::|||...::...|
Human    97 EARAAVRAAYEAF---CRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEIL 158

  Fly   143 PTAIKNLRYFAGWADKNHGKTIPMDG-DFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATG 206
            .:|. .|.:|:..|.:.:|..|.... |.......:|:||...|.|||||..|:..|:|.|||.|
Human   159 YSAF-FLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAG 222

  Fly   207 NTIVLKPAEQTSLTALYIAQ-------------LVKEAGFPEGVVNVVP----GFGTAGAALANH 254
            .|:|:||||.|..:||.:|:             |..:||.|.||.||:|    .....|.|:...
Human   223 CTVVVKPAEDTPFSALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTD 287

  Fly   255 CDVDKVAFTGSTDVGKLIQLASGNTNLKRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQ 319
            ..|.|::|||||..||::...:.| ::|||::||||.:|.|:....::|.||..|....|.|.||
Human   288 PLVSKISFTGSTTTGKILLHHAAN-SVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQ 351

  Fly   320 CCCAGSRTFVEDKIYDEFVERSAERAKKR-TVGNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQG 383
            .|...::..|:..|:|.||:..||..||. .|||.|:..|.|||.:||:.:||:...:.....:|
Human   352 TCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKG 416

  Fly   384 AKLVAGGSRPEGLPGYFVQPTVFADVQDDMTIAREEIFGPVQQLIRFKKLDEVIERANNSEYGLA 448
            |.:|.||.|.: |...|.:||:..:|..||....||.|||:..:|:|...:|.|..||.::.|||
Human   417 ATVVTGGKRHQ-LGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLA 480

  Fly   449 AAVFTKDLDKANYIVGGLRAGTVWVNTYNVLAAQAPFGGYKMSGHGRENGEYALSNYTEVKSV 511
            ...:::|..:...:...|..|.|.||...:.:.:.||||.|.||.|||..:|.:..|.|:|.|
Human   481 GYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	173/518 (33%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	169/497 (34%)
ALDH5A1	NP_733936.1	SSADH	78..541	CDD:188167	162/468 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810