DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and aldh1a3

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001038210.1	Gene:	aldh1a3 / 751785	ZFINID:	ZDB-GENE-061128-2	Length:	513	Species:	Danio rerio

Alignment Length:	492	Identity:	289/492 - (58%)
Similarity:	379/492 - (77%)	Gaps:	2/492 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LPQPQTTPDILYTGVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFKL 92
            ||||....:|.:|.:|||||||.|..||.|.||||.|...|.:|:.|||.|:|.||:||:.|.:.
Zfish    20 LPQPVKITEIKHTKIFINNEWHTSSKGKQFPTINPATGVKICDIEEADKADVDEAVKAAKAAGQR 84

  Fly    93 GSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWAD 157
            ||.|||||||.|||||.|||||:||::..||:||:.|.|||:..::.|||..:||.|||:|||.|
Zfish    85 GSVWRRMDASSRGRLLNRLADLLERERAVLATLESKDTGKPFLHAFFVDLDGSIKTLRYYAGWTD 149

  Fly   158 KNHGKTIPMDGDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTAL 222
            |.||||:|:|.:|..:|:|||:||||.|||||||:||:.||:.||||.|||:||||||||.||||
Zfish   150 KIHGKTMPVDENFVCFTKHEPIGVCGAIIPWNFPLLMLMWKIAPALACGNTVVLKPAEQTPLTAL 214

  Fly   223 YIAQLVKEAGFPEGVVNVVPGFG-TAGAALANHCDVDKVAFTGSTDVGKLIQLASGNTNLKRVTL 286
            ::|.|:||||||.|||||||||| |||||:|.|.::||:||||||:||:|::.|:.::|||||||
Zfish   215 HVAALIKEAGFPPGVVNVVPGFGPTAGAAIAGHMNIDKLAFTGSTEVGQLVKAAAASSNLKRVTL 279

  Fly   287 ELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVG 351
            |||||:|.|:.:|:|:..|||....|.|||.||.|.|.||.:|::.:|:|||..|.||||...:|
Zfish   280 ELGGKNPCIVFADSDLQLAVEETQKGAFFNQGQACTAASRVYVQEPVYEEFVRLSVERAKNIVIG 344

  Fly   352 NPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTIA 416
            :|.:..|..|||:::.|.||||.::.:|||:||||..||...|. .|.|:.||:|:||:|.|.||
Zfish   345 DPMEPRTSHGPQIDQHQFEKILALVDSGKKEGAKLEFGGCAVED-RGLFIHPTIFSDVKDHMRIA 408

  Fly   417 REEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLAA 481
            :||||||||.:::|:...:||:|||:|::||.|||||:|:.:|..:...|.|||||||.||.|.|
Zfish   409 KEEIFGPVQCIMKFECQQDVIDRANSSQFGLTAAVFTRDVQRAMSVSAALEAGTVWVNCYNALHA 473

  Fly   482 QAPFGGYKMSGHGRENGEYALSNYTEVKSVIVKVAQK 518
            |.|||||||||:|||.|||||:.|||||::.:|::::
Zfish   474 QTPFGGYKMSGNGRELGEYALAEYTEVKAITIKLSEQ 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	288/484 (60%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	284/480 (59%)
aldh1a3	NP_001038210.1	ALDH_F1AB_F2_RALDH1	28..506	CDD:143459	284/478 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53964
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100163
Panther	1	1.100	-	-	O	PTHR11699
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X158
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.830