DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and aldh1a2

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001039196.1	Gene:	aldh1a2 / 734052	XenbaseID:	XB-GENE-1012909	Length:	511	Species:	Xenopus tropicalis

Alignment Length:	503	Identity:	326/503 - (64%)
Similarity:	403/503 - (80%)	Gaps:	2/503 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 AAAVANYSSLPQPQTTPDILYTGVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAV 83
            ||.:|:...||.|....::.:|.:||||||..|:||:.|...||.|.|.|.|:|.|:|.|:|.||
Frog    10 AALMASLQLLPSPSANLEVKHTKIFINNEWQTSESGRTFPVYNPATGEQICEVQEAEKADVDKAV 74

  Fly    84 QAARNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKN 148
            ||||.||.|||.|||||||||||||.:||||:||::..||:||:|::|||:..||.|||..|||.
Frog    75 QAARLAFSLGSVWRRMDASERGRLLDKLADLVERERTTLATLESLNSGKPFLQSYYVDLQGAIKT 139

  Fly   149 LRYFAGWADKNHGKTIPMDGDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKP 213
            .||:||||||.||.|||.|||:.|:|||||:||||||||||||:||.|||:.|||..|||:|:||
Frog   140 FRYYAGWADKIHGLTIPADGDYLTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKP 204

  Fly   214 AEQTSLTALYIAQLVKEAGFPEGVVNVVPGFG-TAGAALANHCDVDKVAFTGSTDVGKLIQLASG 277
            ||||.|||||:..|:||||||.||||::||:| :||.|:|:|..:|||||||||:||.|||.|:|
Frog   205 AEQTPLTALYMGALIKEAGFPPGVVNILPGYGPSAGTAIASHIGIDKVAFTGSTEVGMLIQEAAG 269

  Fly   278 NTNLKRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSA 342
            .:|||||||||||||||||.:|.|:|||||.||.|:|||.||||.|||||||||.||:|||.||.
Frog   270 KSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRTFVEDSIYEEFVRRSV 334

  Fly   343 ERAKKRTVGNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPTVFA 407
            ||||:|.||:|||..||||||.:::|..|||.:|::|..:||||..|| :..|..|:|::||||:
Frog   335 ERAKRRIVGSPFDPTTEQGPQTDKKQYNKILELIQSGIAEGAKLECGG-KGLGRKGFFIEPTVFS 398

  Fly   408 DVQDDMTIAREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVW 472
            :|:|:|.||||||||||||::|||.::|||||||||:|||.|||||.|::||..:...::|||||
Frog   399 NVRDEMRIAREEIFGPVQQILRFKTVEEVIERANNSDYGLVAAVFTNDINKALTVSSAMQAGTVW 463

  Fly   473 VNTYNVLAAQAPFGGYKMSGHGRENGEYALSNYTEVKSVIVKVAQKNS 520
            :|.||.|.||:|||||||||:|||.|||.|..|||.|:|.:|:.||||
Frog   464 INCYNALNAQSPFGGYKMSGNGREMGEYGLREYTEAKTVTIKIPQKNS 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	320/493 (65%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	315/480 (66%)
aldh1a2	NP_001039196.1	ALDH_F1AB_F2_RALDH1	25..505	CDD:143459	315/480 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11699
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X158
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110