DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and aldh16a1

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001039089.1	Gene:	aldh16a1 / 733905	XenbaseID:	XB-GENE-5726619	Length:	829	Species:	Xenopus tropicalis

Alignment Length:	467	Identity:	188/467 - (40%)
Similarity:	277/467 - (59%)	Gaps:	19/467 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 GVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERG 105
            |.||:.:|.|.:....:.|.||.|.|.:|.....::||::.||:|||.||:   .|.::....|.
Frog    43 GHFIDGKWLKPEGRNTYTTKNPATGEALASTVQGEEEDVETAVKAARKAFE---SWSKLPCHVRA 104

  Fly   106 RLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTIPMDGDF 170
            |.||.:|..:::.|..|:.:|::|||||...:.:.|:|..:::..:.||||..   :...|:|
Frog   105 RYLYSIARTVQKHQRLLSVIESMDNGKPIREARDCDVPLVVRHFYHHAGWAQL---RDTEMNG-- 164

  Fly   171 FTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTALYIAQLVKEAGFPE 235
                 .:|:||...|:|||||::::.||:.||||.|||:|||||..|.||||.:|::..|||.|.
Frog   165 -----WKPLGVIAAIVPWNFPLMLLTWKICPALAMGNTVVLKPATYTRLTALLLAEICAEAGLPP 224

  Fly   236 GVVNVVPGFGTAGAALANHCDVDKVAFTGSTDVGKLIQLASGNTNLKRVTLELGGKSPNIILSDT 300
            ||.|||.|.|..|..||:|.|||||||||||:||:.::.|:..|. |:::||||||||.|:...:
Frog   225 GVFNVVTGNGAFGGKLADHPDVDKVAFTGSTEVGRTLRKATAGTG-KKLSLELGGKSPFIVFDTS 288

  Fly   301 DMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVGNPFDLNTEQGPQVN 365
            |:|.|||.....::||.||.|.||||..:::.|.::.:.|..:|.....:|:..|...:.|..|:
Frog   289 DLDSAVEGIVDAIWFNQGQVCSAGSRLLMQESIAEDLIRRLKQRMSHLRLGDSLDKAIDVGALVD 353

  Fly   366 EEQMEKILGMIKTGKKQGAKLVAGGSRPEGLP--GYFVQPTVFADVQDDMTIAREEIFGPVQQLI 428
            |.|.:.|...::..:.:||.:.   ..|..:|  |.|..||:...|.......||||||||...:
Frog   354 ETQKKTIEEFVEEAQAEGADVF---QSPGPIPKKGLFYPPTLITGVNTTSRCVREEIFGPVLVAM 415

  Fly   429 RFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLAAQAPFGGYKMSGH 493
            .|:...|.|...||:.|||||:|:|::|..|..:...::|||||||.:|:..|.|.|||||.||.
Frog   416 TFRTAKEAIALGNNTPYGLAASVWTENLPLALEVAISIKAGTVWVNGHNMFDAAAGFGGYKESGF 480

  Fly   494 GRENGEYALSNY 505
            ||:.|:..|..|
Frog   481 GRDGGKEGLYEY 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	188/467 (40%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	188/467 (40%)
aldh16a1	NP_001039089.1	ALDH_F16	21..500	CDD:143429	188/467 (40%)
aldh16a1	NP_001039089.1	ALDH-SF	572..>788	CDD:299846
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910