DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and Aldh16a1

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_666066.1	Gene:	Aldh16a1 / 69748	MGIID:	1916998	Length:	802	Species:	Mus musculus

Alignment Length:	467	Identity:	142/467 - (30%)
Similarity:	225/467 - (48%)	Gaps:	32/467 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 GVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERG 105
            |..:|..|.|.:........:|.|.|.:|....|:.|||..||:||:.|||   .|.::..:.||
Mouse    41 GHHVNGMWLKPEHRNPAPCQDPITGENLASCLQAEAEDIAAAVEAAKIAFK---AWSQLPGAARG 102

  Fly   106 RLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTIPMDGDF 170
            :.|.|||.::::.|..|.:||:|..|:......:.|:|.|.:.|:|.|..|   |.:     ||
Mouse   103 QHLTRLAKVVQKHQRLLWTLESLVTGRAVREVRDGDVPLAQQLLQYHAVQA---HAQ-----GD- 158

  Fly   171 FTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIV--LKPAEQTSLTALYIAQLVKEAGF 233
             .....:||||.|.|:|..|..|.|.|::.||||.|.|:|  :.||..   |.|.:|||..|.|.
Mouse   159 -ALADWQPVGVIGLILPTPFSFLDMMWRVCPALAMGCTVVALVPPAFP---TPLLLAQLAGELGS 219

  Fly   234 PEGVVNVVPGFGTAGAALANHCDVDKVAFTGSTDVGKLIQ--LASGNTNLKRVTLELGGKSPNII 296
            ..|::|||.|..:.|..||:...|.||||.|:.:.|::::  ||.....|   .|.||.:|..::
Mouse   220 FPGILNVVCGPASLGPVLASQPGVQKVAFCGAVEEGRVLRRTLAGRGAEL---GLALGTESLLLL 281

  Fly   297 LSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVGNPFDLNTEQG 361
            :...|:|.|||.....::.:..   ..|.|..:::.::||.:.|...|..:...|...|...:.|
Mouse   282 MDSADVDSAVEGVVDAVWSDRS---LGGLRLLIQESVWDEAMRRLQARMAQIRSGRGLDGAVDMG 343

  Fly   362 PQVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTIAREEIFGPVQQ 426
            .: .....:.....:...:.||.::...|..|...|  |..|.:.:.:......|:.|:..||..
Mouse   344 AR-GAAARDLAQSFVDEAQSQGGQVFQAGDVPSSSP--FFSPALVSGLPPAAPCAQAEVPWPVVM 405

  Fly   427 LIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLAAQAPFGGYKMS 491
            ...|:.:.|.:..||.:..|.:|:|:::.|.:|..:..||:.||||:|.:.:.....|.||.|.|
Mouse   406 ASPFRTVKEALALANGTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPAVPTGGCKES 470

  Fly   492 G---HGRENGEY 500
            |   ||..:|.|
Mouse   471 GSSWHGGPDGLY 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	142/467 (30%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	142/467 (30%)
Aldh16a1	NP_666066.1	ALDH-SF	19..491	CDD:299846	142/467 (30%)
Aldh16a1	NP_666066.1	ALDH-SF	527..>765	CDD:299846
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910