DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and Aldh8a1

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001178017.2	Gene:	Aldh8a1 / 685750	RGDID:	1590218	Length:	487	Species:	Rattus norvegicus

Alignment Length:	490	Identity:	177/490 - (36%)
Similarity:	278/490 - (56%)	Gaps:	20/490 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 DILYTGVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMD 100
            ::|....||..::....|  ..::.:|:|.||..::..:.||:|::||||||.||   ..|....
  Rat     6 ELLMLENFIGGKFLPCNS--YIDSYDPSTGEVYCKVPNSGKEEIEVAVQAAREAF---PAWSSRS 65

  Fly   101 ASERGRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTIP 165
            ..||..:|.|:||::|:....||..|:.|.||..:::..:|:|.::.|.|:||.....:......
  Rat    66 PQERSLILNRVADVLEQSLEELAQAESKDQGKTLTLARTMDIPRSVLNFRFFASSIQHHVSDCTE 130

  Fly   166 MDG-DFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTALYIAQLVK 229
            |.. ....||...|||:.|.|.|||.|:.::.||:.||:|.|||::.||:|.||:||....:|:.
  Rat   131 MSHLGCMHYTVRTPVGIAGLISPWNLPLYLLTWKIAPAIAAGNTVIAKPSELTSVTAWMFCKLLD 195

  Fly   230 EAGFPEGVVNVVPGFGT---AGAALANHCDVDKVAFTGSTDVG-KLIQLASGNTNLKRVTLELGG 290
            :||.|.||:|||  |||   .|.||.:|.:|..::||||.... ::.||::  .:.|:::|||||
  Rat   196 KAGVPPGVINVV--FGTGPRVGEALVSHPEVPVISFTGSQPTAERITQLSA--PHCKKLSLELGG 256

  Fly   291 KSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVGNPFD 355
            |:|.||..|.:::..:.......|.|.|:.|...||.||:..||:||::|..|..:|..||.|.|
  Rat   257 KNPAIIFEDANLEECIPATVRSSFANQGEICLCTSRIFVQRSIYNEFLKRFVEATRKWKVGIPSD 321

  Fly   356 LNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAG-GSRPEGLP-----GYFVQPTVFADVQDDMT 414
            .:...|..:::..:||:...:.....:|||::.| |.....||     |||:.|||..|::|:..
  Rat   322 PSANMGALISKAHLEKVRSYVTKAHAEGAKILCGEGVDQLSLPLRNQAGYFMLPTVITDIKDESC 386

  Fly   415 IAREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVL 479
            ...|||||||..::.|...:|||.|||..:|||.|.|::||:.:.:.:...|::|.||.|.:.:.
  Rat   387 CMTEEIFGPVTCVVPFDSEEEVIARANGVKYGLGATVWSKDVGRIHRVAKRLQSGLVWTNCWLIR 451

  Fly   480 AAQAPFGGYKMSGHGRENGEYALSNYTEVKSVIVK 514
            ....||||.|.||.|||..:.:...:||:|::.:|
  Rat   452 ELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITIK 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	176/486 (36%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	176/488 (36%)
Aldh8a1	NP_001178017.2	ALDH_F8_HMSADH	27..485	CDD:143412	172/464 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910