DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and Aldh1l1

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_071992.2	Gene:	Aldh1l1 / 64392	RGDID:	621294	Length:	902	Species:	Rattus norvegicus

Alignment Length:	503	Identity:	230/503 - (45%)
Similarity:	330/503 - (65%)	Gaps:	19/503 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 NFAAAVANYSSLPQPQTTPDILYTGVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDI 81
            |:.....|..:|..|..        :||..|:..::..|.:.|||||...||.::..|...|:|.
  Rat   407 NYVEKAVNKLTLQMPYQ--------LFIGGEFVDAEGSKTYNTINPTDGSVICQVSLAQVSDVDK 463

  Fly    82 AVQAARNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAI 146
            ||.||:.||:.|. |.:::|.:||||||||||:||:.|..||::|.||.|..|:::....:..:|
  Rat   464 AVAAAKEAFENGL-WGKINARDRGRLLYRLADVMEQHQEELATIEALDAGAVYTLALKTHVGMSI 527

  Fly   147 KNLRYFAGWADKNHGKTIPMD----GDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGN 207
            :..||||||.||..|.|||::    ....|.|:.|||||||.:||||:|::|::||....||.||
  Rat   528 QTFRYFAGWCDKIQGATIPINQARPNRNLTLTKKEPVGVCGIVIPWNYPLMMLSWKTAACLAAGN 592

  Fly   208 TIVLKPAEQTSLTALYIAQLVKEAGFPEGVVNVVPGFGT-AGAALANHCDVDKVAFTGSTDVGKL 271
            |:|:|||:.|.||||..|:|..:||.|:||||::||.|: .|..|::|.||.|:.|||||:|||.
  Rat   593 TVVIKPAQVTPLTALKFAELTLKAGIPKGVVNILPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKH 657

  Fly   272 IQLASGNTNLKRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDE 336
            |..:...:|:|:|:||||||||.||.:|.|::.||:.....:|||.|:.|.|..|.|||:.|:::
  Rat   658 IMKSCALSNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEESIHNQ 722

  Fly   337 FVERSAERAKKRTVGNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSR-PEGLPGYF 400
            ||::..|..:|..:|||.:.:|..|||.:|..:.|::...:.|.|:||.||.||:: |.  ||:|
  Rat   723 FVQKVVEEVEKMKIGNPLERDTNHGPQNHEAHLRKLVEYCQRGVKEGATLVCGGNQVPR--PGFF 785

  Fly   401 VQPTVFADVQDDMTIAREEIFGPVQQLIRFK--KLDEVIERANNSEYGLAAAVFTKDLDKANYIV 463
            .|||||.||:|.|.||:||.|||:..:.||.  .:|.|:.|||.:|:|||:.|||:|::||.|:.
  Rat   786 FQPTVFTDVEDHMYIAKEESFGPIMIISRFADGDVDAVLSRANATEFGLASGVFTRDINKALYVS 850

  Fly   464 GGLRAGTVWVNTYNVLAAQAPFGGYKMSGHGRENGEYALSNYTEVKSV 511
            ..|:||||::||||.....|||||:|.||.|::.||.||:.|..:|:|
  Rat   851 DKLQAGTVFINTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRIKTV 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	230/503 (46%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	226/486 (47%)
Aldh1l1	NP_071992.2	GART	1..203
		Substrate binding. /evidence=ECO:0000250	88..90
		Aldehyde dehydrogenase	417..902		228/493 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820