DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and Aldh4a1

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001128170.1	Gene:	Aldh4a1 / 641316	RGDID:	1624206	Length:	562	Species:	Rattus norvegicus

Alignment Length:	476	Identity:	122/476 - (25%)
Similarity:	213/476 - (44%)	Gaps:	39/476 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 IAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERGRLLYRLADLM---ERDQVYLASLETLD 129
            :|:...|||..::.|::||..|.|   .|.....::|.::..:.||::   .|.::...::  :.
  Rat    90 VAKFCYADKALLNKAIEAAVLARK---EWDLKPVADRAQIFLKAADMLSGPRRAEILAKTM--VG 149

  Fly   130 NGKPYSMSYNVDLPTAIKNLRYFAGWADKNHGK---TIPMDGDFFTYTRHEPVGVCGQIIPWNFP 191
            .||....:........|...|:.|.:|.:..|:   ::|...:...|...|  |....|.|:||.
  Rat   150 QGKTVIQAEIDAAAELIDFFRFNAKFAVELEGEQPISVPPSTNHVVYRGLE--GFVAAISPFNFT 212

  Fly   192 ILMMAWKLGPALATGNTIVLKPAEQTSLTALYIAQLVKEAGFPEGVVNVVPG----FGTAGAALA 252
            .:.......||| .||.::.||::...|.:..:.::::|||.|..|:..||.    ||....:..
  Rat   213 AIGGNLAGAPAL-MGNVVLWKPSDTAMLASYAVYRILREAGLPPNVIQFVPADGPTFGDTVTSSE 276

  Fly   253 NHCDVDKVAFTGSTDVGKLI--QLASGNTNLK---RVTLELGGKSPNIILSDTDMDYAVETAHFG 312
            :.|.::   ||||....|.:  |:|......:   |:..|.|||:.:.:.|..|:|..|......
  Rat   277 HLCGIN---FTGSVPTFKHLWKQVAQNLDRFRTFPRLAGECGGKNFHFVHSSADVDSVVSGTLRS 338

  Fly   313 LFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVGNPF-DLNTEQGPQVNEEQMEKILGMI 376
            .|...||.|.|.||.:|...::.:...|..|...:..||||. |..|.....::.:...:|...:
  Rat   339 AFEYGGQKCSACSRLYVPQSLWPQIKGRLLEEHSRIKVGNPAEDFGTFFSAVIDAKAFARIKKWL 403

  Fly   377 KTGKKQ-GAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTIAREEIFGPVQQLIRF--KKLDEVIE 438
            :..:.. ...::|||...|.: ||||:|.:.........|.:|||||||..:..:  :|..|.::
  Rat   404 EHARSSPSLSILAGGQCNESV-GYFVEPCIIESKDPQEPIMKEEIFGPVLTVYVYPDEKYRETLQ 467

  Fly   439 RANN-SEYGLAAAVFTKDLDKANYIVGGLR--AGTVWVNTYNV--LAAQAPFGGYKMSG-HGREN 497
            ..:: :.|||..|||.:|..........||  ||..::|..:.  :..|.||||.:.|| :.:..
  Rat   468 LVDSTTSYGLTGAVFAQDKTIVQEATRMLRNAAGNFYINDKSTGSVVGQQPFGGARASGTNDKPG 532

  Fly   498 GEYALSNYTEVKSVIVKVAQK 518
            |.:.:..:|..:  ::|...|
  Rat   533 GPHYILRWTSPQ--VIKETHK 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	120/468 (26%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	120/470 (26%)
Aldh4a1	NP_001128170.1	ALDH_F4-17_P5CDH	31..552	CDD:143441	122/476 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910