DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and Aldh9a1

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_071609.2	Gene:	Aldh9a1 / 64040	RGDID:	68409	Length:	497	Species:	Rattus norvegicus

Alignment Length:	496	Identity:	188/496 - (37%)
Similarity:	295/496 - (59%)	Gaps:	21/496 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 TGVFINNEWHKSKSGKIFETIN---------PTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSP 95
            ||.|:.::....:.|...|.::         |.|...||..:|:.::::::||:.|:.|||:
  Rat     3 TGTFVVSQPLNYRGGARVEPVDASGTEKAFEPATGREIATFKCSGEKEVNLAVENAKAAFKI--- 64

  Fly    96 WRRMDASERGRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWADKNH 160
            |.:....||.::|...|.:::..:..:|.:||::|||.. ....:|:.|:.:.|.|:||.|....
  Rat    65 WSKKSGLERCQVLLEAARIIKERRDEIAIMETINNGKSI-FEARLDVDTSWQCLEYYAGLAASMA 128

  Fly   161 GKTIPMDGDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTALYIA 225
            |:.|.:.|..|.|||.||:|||..|..||:|..:..||..||||.||.::.||:..|.::||.:|
  Rat   129 GEHIQLPGGSFGYTRREPLGVCLGIGAWNYPFQIACWKSAPALACGNAMIFKPSPFTPVSALLLA 193

  Fly   226 QLVKEAGFPEGVVNVVPGFGTAGAALANHCDVDKVAFTGSTDVG-KLIQLASGNTNLKRVTLELG 289
            ::..:||.|.|:.|||.|....|..|..|.||.||:||||...| |::::|:  ..:|.:|||||
  Rat   194 EIYTKAGAPNGLFNVVQGGAATGQFLCQHRDVAKVSFTGSVPTGMKIMEMAA--KGIKPITLELG 256

  Fly   290 GKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVGNPF 354
            ||||.||.||.:|..||:.|....|...||.||.|:|.||:.:|.|.|.:....:.::..:|:|.
  Rat   257 GKSPLIIFSDCNMKNAVKGALLANFLTQGQVCCNGTRVFVQKEIADAFTKEVVRQTQRIKIGDPL 321

  Fly   355 DLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGG-----SRPEGLPGYFVQPTVFADVQDDMT 414
            ..:|..||.:|...:|::||.:::.|:|||.::.||     ..|:...||::.|.:..:..||||
  Rat   322 LEDTRMGPLINAPHLERVLGFVRSAKEQGATVLCGGEPYAPEDPKLKHGYYMTPCILTNCTDDMT 386

  Fly   415 IAREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVL 479
            ..:|||||||..::.|:...||:||||::.:||||.|||:|:.:|:.:...|:|||.::|.|||.
  Rat   387 CVKEEIFGPVMSILTFETEAEVLERANDTTFGLAAGVFTRDIQRAHRVAAELQAGTCYINNYNVS 451

  Fly   480 AAQAPFGGYKMSGHGRENGEYALSNYTEVKSVIVKVAQKNS 520
            ..:.||||||.||.|||||...:..|:::|:|.|::....|
  Rat   452 PVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGDVES 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	185/486 (38%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	186/488 (38%)
Aldh9a1	NP_071609.2	ALDH_F9_TMBADH	31..488	CDD:143409	182/462 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810