DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and aldh1a1

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001027486.1	Gene:	aldh1a1 / 613078	XenbaseID:	XB-GENE-987058	Length:	502	Species:	Xenopus tropicalis

Alignment Length:	494	Identity:	320/494 - (64%)
Similarity:	406/494 - (82%)	Gaps:	2/494 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LPQPQTTPDILYTGVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFKL 92
            ||.|.:..:|.|..:|||||||.|.|||.|...||.|.|.|.|::..||||::.||:|||.||::
Frog    10 LPAPISNLEIKYRKIFINNEWHNSVSGKKFPVYNPATGEKICEVEEGDKEDVNKAVKAAREAFQI 74

  Fly    93 GSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWAD 157
            ||||||:|||||||:|.:||||:|||:..|:::|::|.|||::.||..|:|.|||:|||.|||||
Frog    75 GSPWRRLDASERGRILNKLADLVERDRSILSTMESIDGGKPFAASYYGDIPGAIKSLRYCAGWAD 139

  Fly   158 KNHGKTIPMDGDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTAL 222
            ||.|:|||||||:||:||||||||||||||||||::|.|||:.|||..|||:|:||||||.||||
Frog   140 KNQGRTIPMDGDYFTFTRHEPVGVCGQIIPWNFPLVMFAWKIAPALCCGNTVVIKPAEQTPLTAL 204

  Fly   223 YIAQLVKEAGFPEGVVNVVPGFG-TAGAALANHCDVDKVAFTGSTDVGKLIQLASGNTNLKRVTL 286
            |:..|:||||.|.||||:|||:| |||||:|.|.::|||||||||:|||||:.|:|.:|||||||
Frog   205 YMGSLIKEAGIPPGVVNIVPGYGPTAGAAIAYHMEIDKVAFTGSTEVGKLIKEAAGKSNLKRVTL 269

  Fly   287 ELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVG 351
            ||||||||||.:|.|:|.|||.||.||||:.||||.||||.|||:.||||||.:|.||||||.:|
Frog   270 ELGGKSPNIIFADADLDLAVEHAHNGLFFHQGQCCIAGSRIFVEEPIYDEFVRKSVERAKKRVLG 334

  Fly   352 NPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTIA 416
            :|......||||::::|.:|||.:|::|||:||||..||| ..|..|:::.||||:||:|||.||
Frog   335 DPLSPCVNQGPQIDKDQFDKILELIESGKKEGAKLECGGS-AWGEKGFYISPTVFSDVKDDMRIA 398

  Fly   417 REEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLAA 481
            :|||||||||:::||::||||:||||:.|||||.|||||:|||..:...|:|||||:|.|:.::.
Frog   399 KEEIFGPVQQILKFKRIDEVIKRANNTNYGLAAGVFTKDMDKAILMSTALQAGTVWINCYSAMSP 463

  Fly   482 QAPFGGYKMSGHGRENGEYALSNYTEVKSVIVKVAQKNS 520
            |:||||:||||:|||.|||.|..|||||:||:|::||||
Frog   464 QSPFGGFKMSGNGREMGEYGLHEYTEVKTVIMKISQKNS 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	313/484 (65%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	312/480 (65%)
aldh1a1	NP_001027486.1	ALDH_F1AB_F2_RALDH1	16..496	CDD:143459	312/480 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11699
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2025
SonicParanoid	1	1.000	-	-		X158
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.140