DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and Aldh1a3

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_444310.3	Gene:	Aldh1a3 / 56847	MGIID:	1861722	Length:	512	Species:	Mus musculus

Alignment Length:	494	Identity:	304/494 - (61%)
Similarity:	394/494 - (79%)	Gaps:	2/494 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SLPQPQTTPDILYTGVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFK 91
            :||:|....::.:|.:||||:||:||||:.|.|.||:|.|.|.|::..||.|:|.||:||:.||:
Mouse    19 ALPRPIRNLEVKFTKIFINNDWHESKSGRKFATYNPSTLEKICEVEEGDKPDVDKAVEAAQAAFQ 83

  Fly    92 LGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWA 156
            .||||||:||..||:||::||||:|||:..||:|||:|.|||:..::.|||...||..|||||||
Mouse    84 RGSPWRRLDALSRGQLLHQLADLVERDRAILATLETMDTGKPFLHAFFVDLEGCIKTFRYFAGWA 148

  Fly   157 DKNHGKTIPMDGDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTA 221
            ||..|:|||.|.:...:|||||:||||.|.|||||:||:||||.|||..|||:||||||||.|||
Mouse   149 DKIQGRTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLAWKLAPALCCGNTVVLKPAEQTPLTA 213

  Fly   222 LYIAQLVKEAGFPEGVVNVVPGFG-TAGAALANHCDVDKVAFTGSTDVGKLIQLASGNTNLKRVT 285
            ||:|.|:||.|||.||||:||||| |.|||:::|..::|:||||||:||||::.|:..:||||||
Mouse   214 LYLASLIKEVGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVREAASRSNLKRVT 278

  Fly   286 LELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTV 350
            ||||||:|.|:.:|.|:|.|||.||.|:|||.||||.|.||.|||:::|.|||.||.|.||||.|
Mouse   279 LELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYGEFVRRSVEFAKKRPV 343

  Fly   351 GNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTI 415
            |:|||..||||||::::|.:|||.:|::|||:||||..|||..|. .|.|::||||:||.|:|.|
Mouse   344 GDPFDAKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMED-RGLFIKPTVFSDVTDNMRI 407

  Fly   416 AREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLA 480
            |:||||||||.:::||.|:|||:|||:::|||.||||||:||||..:...|.:||||:|.||...
Mouse   408 AKEEIFGPVQPILKFKNLEEVIKRANSTDYGLTAAVFTKNLDKALKLAAALESGTVWINCYNAFY 472

  Fly   481 AQAPFGGYKMSGHGRENGEYALSNYTEVKSVIVKVAQKN 519
            |||||||:||||:|||.|||||:.|||||:|.:|:.:||
Mouse   473 AQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIKLEEKN 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	300/485 (62%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	298/480 (62%)
Aldh1a3	NP_444310.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		1/2 (50%)
Aldh1a3	NP_444310.3	ALDH_F1AB_F2_RALDH1	26..506	CDD:143459	298/480 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53964
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100163
Panther	1	1.100	-	-	O	PTHR11699
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X158
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.830