DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and aldh3b2

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_009299655.1	Gene:	aldh3b2 / 557008	ZFINID:	ZDB-GENE-060531-79	Length:	501	Species:	Danio rerio

Alignment Length:	525	Identity:	118/525 - (22%)
Similarity:	203/525 - (38%)	Gaps:	101/525 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SSLPQPQTTPDILYTGVFINNEWHKS-KSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNA 89
            ||.|.|..|            .|.|: :..::.:....|...|.:|:           ::.||.|
Zfish     2 SSPPSPSPT------------RWFKALRRSRVEDVCVKTGVSVCSEV-----------LRRARAA 43

  Fly    90 FKLGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPT-------AIK 147
            |..|.  ...|.....:|...|..||:.:..::.:|.. |..||...:...:|..       ||.
Zfish    44 FSAGR--TAQDTFRLAQLEALLRMLMDHECDFVDALGR-DVHKPRFETVMSELLVVKNEALHAIS 105

  Fly   148 NLRYFAGWADKNHGKTIPMDGDFFT-----YTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGN 207
            ||:   .|.:...     ::.|:.|     ...:||:|:...|..|..|:.:....|..|:|.||
Zfish   106 NLK---KWMEPQR-----IERDWATAFDECVLVNEPLGLVLIIGNWTSPLQLCLVPLVGAIAAGN 162

  Fly   208 TIVLKPAEQTSLTALYIAQLVKEAGFPEGVVNVVPGFGTAGAALANHC----------------- 255
            ..::.|:|..:.||..:.:|:.                   |.|.|.|
Zfish   163 CAIISPSETCTHTAGLLHRLIP-------------------AYLDNECFHSVIAAAHEIPEIVDL 208

  Fly   256 DVDKVAFTGSTDVGKLIQLASGNTNLKRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQC 320
            ..|.|.|:|..:.|..:..|:..| |.||||.|..|:|..:.|..|::.......:..|.|.||.
Zfish   209 TFDYVFFSGDKEDGIKVAQAAART-LARVTLVLRVKNPCYVDSQCDINTTARRITWARFHNAGQS 272

  Fly   321 CCAGSRTFVEDKIYDEFVERSAERAKKRTVGNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQ--- 382
            ..|........::.:..:: :...:.::..|.....:...|..||||...|       .|:|
Zfish   273 AVAPDYILCHAEVKENLLQ-ALRCSLQQFYGTDPRESRSFGRIVNEENFSK-------AKEQLWG 329

  Fly   383 GAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTIAREEIFGPVQQLIRFKKLDEVIERANNSEYGL 447
            ..|::.||...| :..| :.|||..||.:...|..:::|||:..::..:..||.:...|:.|..|
Zfish   330 SGKVIIGGQVNE-IERY-IAPTVLMDVMESDPIMHQDVFGPILPILTVQDADEAVAFINSREKPL 392

  Fly   448 AAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLAA---QAPFGGYKMSGHGRENGEYALSNYTEVK 509
            ....::.:....:.|:....:|:...|. :||.:   ..||||...||.|..:|.|:...::..|
Zfish   393 CVYAYSSNNKVISKIMNETSSGSFCSND-SVLQSVMVGLPFGGVGASGMGSYHGRYSFDAFSHKK 456

  Fly   510 SVIVK 514
            |.:::
Zfish   457 SCLLR 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	118/521 (23%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	114/515 (22%)
aldh3b2	XP_009299655.1	ALDH_F3AB	34..477	CDD:143450	109/481 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910