Protein Alignment Aldh and ALDH7A1

DIOPT Version :9

• Sequence 1: NP_001260290.1
• Gene: Aldh / 34256
• FlyBaseID: FBgn0012036
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_001173.2
• Gene: ALDH7A1 / 501
• HGNCID: 877
• Length: 539
• Species: Homo sapiens
• Alignment Length: 480
• Identity: 152/480 - (31%)
• Similarity: 232/480 - (48%)
• Gaps: 31/480 - (6%)

  Fly    41 GVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERG 105
            ||: |..|  ...|::..|..|...|.||.::.|...|.:..|:.||.|:|:   |..:.|.:||
Human    53 GVY-NGSW--GGRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKI---WADIPAPKRG 111

  Fly   106 RLLYRLAD-LMERDQVYLASLETLDNGKPY-----SMSYNVDLPTAIKNLRYFAGWADKNHGKTI 164
            .::.::.| |.|:.|| |.||.:|:.||..     .:...||:      ..|..|.:....|..:
Human   112 EIVRQIGDALREKIQV-LGSLVSLEMGKILVEGVGEVQEYVDI------CDYAVGLSRMIGGPIL 169

  Fly   165 PMD-GDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTAL----YI 224
            |.: .......:..|||:.|.|..:|||:.:..|....|:..||..:.|.|..|||.::    .|
Human   170 PSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKII 234

  Fly   225 AQLVKEAGFPEGVVNVVPGFGTAGAALANHCDVDKVAFTGSTDVGKLIQLASGNTNLKRVTLELG 289
            |:::::...|..:.::..|....|.|:|....|:.::|||||.|||.:.|.. .....|..||||
Human   235 AKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMV-QERFGRSLLELG 298

  Fly   290 GKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVGNPF 354
            |.:..|...|.|:...|.:|.|......||.|....|.|:.:.|:||.|.|..:...:..||||:
Human   299 GNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPW 363

  Fly   355 DLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTIAREE 419
            |.|...||...::.:...||.::..||:|..:|.|| :....||.:|:||:...:..|.:||..|
Human   364 DPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGG-KVMDRPGNYVEPTIVTGLGHDASIAHTE 427

  Fly   420 IFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVG--GLRAGTVWVN--TYNVLA 480
            .|.|:..:.:||..:||....|..:.||::::|||||.:....:|  |...|.|.||  |.....
Human   428 TFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEI 492

  Fly   481 AQAPFGGYKMSGHGRENGEYALSNY 505
            ..| |||.|.:|.|||:|..|...|
Human   493 GGA-FGGEKHTGGGRESGSDAWKQY 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	152/480 (32%)
		ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	152/480 (32%)
ALDH7A1	NP_001173.2	ALDH_F7_AASADH	53..527	CDD:143448	152/480 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810