DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and aldh1l1

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001011027.1	Gene:	aldh1l1 / 496436	XenbaseID:	XB-GENE-1016237	Length:	902	Species:	Xenopus tropicalis

Alignment Length:	480	Identity:	230/480 - (47%)
Similarity:	330/480 - (68%)	Gaps:	9/480 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERGR 106
            :|||.::..::.||.::|:|||....|.::..|...|||.||.||:.||:.|. |.:|:..:|||
Frog   424 LFINGQFIDAEGGKTYDTVNPTDGTAICKVSLAQVSDIDRAVAAAKEAFENGE-WGKMNPRDRGR 487

  Fly   107 LLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTIPMD---- 167
            :||||||:||..|..||::|::|:|..|:::....:..:|:..||||||.||..|.|||::
Frog   488 ILYRLADIMEEHQEELATIESIDSGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGSTIPINQARP 552

  Fly   168 GDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTALYIAQLVKEAG 232
            ....|:||.||:||||.:||||:|::|:|||....||.|||:|||||:.|.||||..|:|..:||
Frog   553 NRNLTFTRREPIGVCGIVIPWNYPLMMLAWKTAACLAAGNTVVLKPAQVTPLTALKFAELSVKAG 617

  Fly   233 FPEGVVNVVPGFGT-AGAALANHCDVDKVAFTGSTDVGKLIQLASGNTNLKRVTLELGGKSPNII 296
            .|:||:|::||.|: .|..|::|.||.|:.|||||.:||.|..:....|:|:|:||||||||.||
Frog   618 IPKGVINILPGAGSLIGQRLSDHPDVRKIGFTGSTPIGKHIMKSCAVGNVKKVSLELGGKSPLII 682

  Fly   297 LSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVGNPFDLNTEQG 361
            ..|.|:|.||......:|||.|:.|.|..|.|:|:.|:||||:|.....||..:|:|.|.:|:.|
Frog   683 FQDCDLDKAVRMGMSSVFFNKGENCIAAGRLFLEESIHDEFVKRVVGEVKKMKIGDPLDRSTDHG 747

  Fly   362 PQVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTIAREEIFGPVQQ 426
            ||.::..::|::...:||.|:|||||.||.:.| .||:|.:||:|.||.|:|.||:||.|||:..
Frog   748 PQNHKAHLDKLIEYCQTGVKEGAKLVYGGKQVE-RPGFFFEPTIFTDVTDEMFIAKEESFGPIMI 811

  Fly   427 LIRFK--KLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLAAQAPFGGYK 489
            :.:||  .:|||::||||:|:|||:.|||||:.||.|:...|:||||:|||||.....|||||:|
Frog   812 ISKFKDGDVDEVLKRANNTEFGLASGVFTKDISKALYVSEKLQAGTVFVNTYNKTDVAAPFGGFK 876

  Fly   490 MSGHGRENGEYALSNYTEVKSVIVK 514
            .||.|::.||.||:.|.:.|:|.::
Frog   877 QSGFGKDLGEEALNEYLKTKAVTIE 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	229/476 (48%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	230/478 (48%)
aldh1l1	NP_001011027.1	FMT_core_FDH_N	1..203	CDD:187716
		GART	1..203
		FDH_Hydrolase_C	206..305	CDD:187731
		PP-binding	325..391	CDD:376348
		ALDH_F1L_FTFDH	417..902	CDD:143458	230/480 (48%)
		Aldehyde dehydrogenase	417..902		230/480 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920