DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and aldh16a1

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001073423.2	Gene:	aldh16a1 / 492710	ZFINID:	ZDB-GENE-070112-2062	Length:	795	Species:	Danio rerio

Alignment Length:	475	Identity:	123/475 - (25%)
Similarity:	209/475 - (44%)	Gaps:	54/475 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 GVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERG 105
            |.||:.::......:..:.|: :.|.|:....||..||:..||.:|...||   .|.::...:|.
Zfish    40 GFFIDGKFSHPADRQTQDVID-SKAAVVCSTVCAQAEDVASAVSSAAAGFK---TWSQLSCYQRA 100

  Fly   106 RLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNL-RYFAGWADKNHGKTIPMDGD 169
            ::|.:|..:::|....::.:        ..:|.:...|..:..| :|:|.||.....: :|
Zfish   101 KVLLKLPGVLQRHSQCVSEV--------CELSQSTTSPAVLIRLAQYYASWAQLRDTR-MP---- 152

  Fly   170 FFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTALYIAQLVKEAGFP 234
                 ...|.||...::..:..:..:..|:.||||.||.:::.|.:.|:|..|.:|||..|||.|
Zfish   153 -----EWSPQGVVTVVVSDDCSVYFLLLKVLPALAMGNAVIVVPGKTTALPGLLLAQLFMEAGMP 212

  Fly   235 EGVVNVVPGF-GTAGAALANHCDVDKVAFTGSTDVGKLIQLASGNTNLKRVTLELGGKS--PNII 296
            .||:||:.|. .:..|.:|.:..|:.:.|:|....|:.:..|:....:. :|..|...|  |.||
Zfish   213 AGVLNVLTGSEASLAAKMAQNPQVNYLTFSGCRQTGEAVAKAAAGWGVP-MTFSLSSSSVCPFII 276

  Fly   297 LSDTDMDYAVETAHFGLFFNMGQCCCAGSRTF-----VEDKIYDEFVERSAER-AKKRTVGNPFD 355
            ....|:|.||:    |:.    :......|.|     |::.:.|..|.|...| |:.:.|
Zfish   277 FESADLDSAVD----GVI----ELAFKKKRDFQWVLCVQESVLDSVVARLKTRMAEMKGV----- 328

  Fly   356 LNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTIAREEI 420
                  |..::.....|...|:..::|||.|:.  |.|....|....|||...:...........
Zfish   329 ------PLASDPDRSIIDAAIQEAQQQGATLIQ--SCPPASTGGLYPPTVLCGLAPSCESVISPP 385

  Fly   421 FGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLAAQAPF 485
            .|||..||.|:...|.:...|:|.:|.||:::|:||..|......|..|:||||.::|:....|.
Zfish   386 PGPVLPLITFRSSAEGVTLGNHSPHGQAASIWTEDLTLALESAKSLCVGSVWVNCHSVMDPALPL 450

  Fly   486 GGYKMSGHGRENGEYALSNY 505
            .|.:.||:..:.|...|..:
Zfish   451 CGRRDSGNCTDGGREGLYQF 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	123/475 (26%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	123/475 (26%)
aldh16a1	NP_001073423.2	ALDH-SF	18..470	CDD:299846	123/473 (26%)
aldh16a1	NP_001073423.2	AdhE	514..>755	CDD:223944
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810