DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and Aldh-III

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_724562.2	Gene:	Aldh-III / 45398	FlyBaseID:	FBgn0010548	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	532	Identity:	145/532 - (27%)
Similarity:	233/532 - (43%)	Gaps:	73/532 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GALLRSQAKNFAAAVANYSSLPQPQTTPDILYTGVFINNEWHKSKSGKIFETINPTTAEVIAEIQ 72
            ||.:.:........|.|..  |:|:|...|   |:|.:..          |:......::.:|.:
  Fly    14 GAPINAAGDRPITTVINIE--PEPETESPI---GIFTSQP----------ESQQQQPEQLQSESE 63

  Fly    73 CADKEDIDIAVQAARNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDNGKPYSMS 137
            .....:.|..:|.||.||..|   :..:.|.|.:.|..|....|..:..:.|....|..:|...|
  Fly    64 SDRMANFDDTLQRARLAFSSG---KTRNVSFRRKQLENLLRCYEEHENEIISALEADLRRPKQES 125

  Fly   138 YNVDLPTAIKNLRYFA----GW--ADKNHGKTIPMDGDFFTYTRHEPVGVCGQIIPWNFPILMMA 196
            ..|:......::|:..    .|  ::|.....:.|..|...|  ::|.||...|..||:|:.::.
  Fly   126 LIVETEFMKNDIRHILFQLDEWVQSEKPPKSFVNMMDDVQIY--NDPFGVVLVIGAWNYPLQLLL 188

  Fly   197 WKLGPALATGNTIVLKPAEQTSLTALYIAQLVKEAGFPEGVVN----VVPGFGTAGAALANHCDV 257
            ..:..|:|.||.:|:||:|..:..|.:||.::     |:.:.|    ||.|..:..|.|.|. ..
  Fly   189 VPVASAIAAGNCVVIKPSEIAANCAKFIADVI-----PKYLDNDCYPVVCGGPSETAELLNQ-RF 247

  Fly   258 DKVAFTGSTDVGKLIQLASGNTNLKRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCC 322
            |.:.:||||.|||:|. |:.|..|...|||||||||..|....||..||:...:|...|.||.|.
  Fly   248 DYIFYTGSTRVGKIIH-AAANKYLTPTTLELGGKSPCYIDKSVDMRTAVKRILWGKLINCGQTCI 311

  Fly   323 AGSRTFVEDKIYDEFVERSAERAKKRTVGNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLV 387
            |........::.::|:. .|:...|...|.....:.:....:|....:::||::|:|     ::.
  Fly   312 APDYILCSKEVQEKFIV-EAKDVLKEWYGENIQSSPDLSRVINANNFQRLLGLMKSG-----RVA 370

  Fly   388 AGGSRPEGLPGY-----FVQPTVFADVQDDMTIAREEIFGPVQQLIRFKKLDEVIERANNSEYGL 447
            .||:       |     |::||:..||::...|..||||||:..:...:...:.|:..|..|..|
  Fly   371 VGGN-------YDASERFIEPTILVDVKETDPIMEEEIFGPILPIFNVESAYDAIKFINAREKPL 428

  Fly   448 AAAVFTKDLDKANYIV---------GGLRAG-TVWVNTYNVLAAQAPFGGYKMSGHGRENGEYAL 502
            ...||:    .:|.:|         ||..:. |:.....:||    ||||..|||.||.:|:|..
  Fly   429 VIYVFS----NSNKLVKEFRRSTTSGGFSSNETIMHCGVDVL----PFGGVGMSGMGRYHGKYGF 485

  Fly   503 SNYTEVKSVIVK 514
            ..:|..||.:.|
  Fly   486 ETFTHKKSCLGK 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	143/527 (27%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	137/504 (27%)
Aldh-III	NP_724562.2	ALDH_F3AB	72..515	CDD:143450	132/459 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454104
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740