DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and aldh9a1

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_012816342.1	Gene:	aldh9a1 / 448752	XenbaseID:	XB-GENE-951247	Length:	518	Species:	Xenopus tropicalis

Alignment Length:	498	Identity:	198/498 - (39%)
Similarity:	296/498 - (59%)	Gaps:	21/498 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LYTGVFINNEWHKSKSGKIFETIN---------PTTAEVIAEIQCADKEDIDIAVQAARNAFKLG 93
            |.||.|.|......:.|...:.::         |:|..||:...|:.:::::.|:|:|::|||:
Frog    25 LTTGTFQNTLPLNYRGGSRVQPVDSVGEEKAYEPSTGRVISTFACSGEKEVNEAIQSAKSAFKI- 88

  Fly    94 SPWRRMDASERGRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWADK 158
              |.:....||.|:|...|.::......:|::||::|||.. ....||:..:.:.|.|:||.|..
Frog    89 --WSQKSGMERSRVLLEAARIIRERSEEIAAMETINNGKSI-FEARVDVEISWQTLEYYAGHAGA 150

  Fly   159 NHGKTIPMDGDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTALY 223
            ..|:.:.:.|..|.|||.||:|||..|..||:|..:..||.|||||.||.:|.||:..|.:|.:.
Frog   151 MAGQHVQLPGGSFGYTRREPLGVCVGIGAWNYPFQIACWKAGPALACGNAMVYKPSPFTPVTVVL 215

  Fly   224 IAQLVKEAGFPEGVVNVVPGFGTAGAALANHCDVDKVAFTGSTDVG-KLIQLASGNTNLKRVTLE 287
            :|::..|||.|.|:.|||.|..|.|..|..|.||.||:||||...| |::::|:  .::|.||||
Frog   216 LAEIFAEAGVPPGLFNVVQGGATTGEFLCKHPDVAKVSFTGSVPTGSKIMEMAA--KSIKPVTLE 278

  Fly   288 LGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVGN 352
            ||||||.||.||:|::.||..|....|...||.||.|:|.||:..|.::|.|...::.||..:|:
Frog   279 LGGKSPLIIFSDSDLENAVNGAMMANFLTQGQVCCNGTRVFVQRDILEKFTEEVVKKVKKIKIGD 343

  Fly   353 PFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGG-----SRPEGLPGYFVQPTVFADVQDD 412
            |...:|..||.||..|::::.|.:||.::||||.:.||     ..|:...|:|:.|.|.....|.
Frog   344 PLLEDTRMGPIVNRIQLDRVFGFLKTAREQGAKFLIGGEPYSPEDPKLKGGFFMTPCVLGGCTDA 408

  Fly   413 MTIAREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYN 477
            ||..:|||||||..::.|...:||:||||.:.||||..|||:|:.:|:.:|..|:||..::|.||
Frog   409 MTCVKEEIFGPVMSILPFDNEEEVLERANATTYGLAGGVFTRDIQRAHRVVAALQAGMCFINNYN 473

  Fly   478 VLAAQAPFGGYKMSGHGRENGEYALSNYTEVKSVIVKVAQKNS 520
            |...:.||||||.||.|||||..|:.:|:::|:|.|::....|
Frog   474 VSPVELPFGGYKKSGFGRENGWAAMEHYSQLKTVCVEMGNVES 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	195/488 (40%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	196/490 (40%)
aldh9a1	XP_012816342.1	ALDH_F9_TMBADH	55..512	CDD:143409	191/462 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000