DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and CG31075

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001247324.1	Gene:	CG31075 / 43244	FlyBaseID:	FBgn0051075	Length:	508	Species:	Drosophila melanogaster

Alignment Length:	485	Identity:	271/485 - (55%)
Similarity:	358/485 - (73%)	Gaps:	6/485 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 QTTPDILYTGVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPW 96
            |..|:  |..:|||||:..|.|||.|.|.||.|::.|.::...||.|||:||:||:.||...|.|
  Fly    28 QCEPN--YCQLFINNEFVDSVSGKTFATFNPATSKEIVQVSEGDKADIDLAVKAAKKAFHRDSEW 90

  Fly    97 RRMDASERGRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWADKNHG 161
            |::...:|..|:.:|..||:||:.:||||||.||||||:.:. .|:..:|..|:|:|||.||..|
  Fly    91 RKLSPLQRTNLMNKLCALMDRDKAFLASLETQDNGKPYAEAL-FDVTYSILTLQYYAGWTDKFFG 154

  Fly   162 KTIPMDGDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTALYIAQ 226
            .|||. |.|.:.||.|||||.|||||||:|:||:|||.|||||.|.||::||||||.||||::|.
  Fly   155 DTIPA-GGFVSMTRKEPVGVVGQIIPWNYPLLMLAWKWGPALAVGCTIIMKPAEQTPLTALHMAA 218

  Fly   227 LVKEAGFPEGVVNVVPGFG-TAGAALANHCDVDKVAFTGSTDVGKLIQLASGNTNLKRVTLELGG 290
            |.||||||.||:|||.||| |||||::.|.|:.|||||||.::|:::..|:..:|||||:|||||
  Fly   219 LAKEAGFPAGVINVVNGFGPTAGAAISAHPDIAKVAFTGSVEIGRIVMQAAATSNLKRVSLELGG 283

  Fly   291 KSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVGNPFD 355
            |||.::..|.|:|:||||.|..||.|.||.|||||||:|.:|||||||.::|.:||.|.|||||:
  Fly   284 KSPVVVFDDADIDFAVETTHEALFSNHGQSCCAGSRTYVHEKIYDEFVAKAAAKAKARKVGNPFE 348

  Fly   356 LNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTIAREEI 420
            .|.:||||::::.:.|:||.|::|||:||||.|||.| .|..|:||:||||:||:|||.||:|||
  Fly   349 QNVQQGPQIDDDMLTKVLGYIESGKKEGAKLQAGGKR-IGNVGFFVEPTVFSDVKDDMRIAQEEI 412

  Fly   421 FGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLAAQAPF 485
            |||||.:.:|..|:|:|:||||.:|||||.|.|.|::||......:.||:||:|.|:.:....||
  Fly   413 FGPVQSIFKFSSLEEMIDRANNVQYGLAAGVITNDINKALKFANNVDAGSVWINCYDAVLPSTPF 477

  Fly   486 GGYKMSGHGRENGEYALSNYTEVKSVIVKV 515
            ||||.||.|||.|:..|.||.|.|::.:|:
  Fly   478 GGYKHSGIGRELGKDGLDNYLETKTITMKL 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	270/480 (56%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	269/480 (56%)
CG31075	NP_001247324.1	ALDH-SF	33..506	CDD:299846	268/475 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454106
Domainoid	1	1.000	389	1.000	Domainoid score	I16
eggNOG	1	0.900	-	-		E1_COG1012
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	388	1.000	Inparanoid score	I51
Isobase	1	0.950	-	0	Normalized mean entropy	S334
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	1	1.000	-	-		otm51311
orthoMCL	1	0.900	-	-		OOG6_100163
Panther	1	1.100	-	-	P	PTHR11699
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2025
SonicParanoid	1	1.000	-	-		X158
	13	12.780