DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and elp3

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001001215.1	Gene:	elp3 / 407885	XenbaseID:	XB-GENE-957348	Length:	549	Species:	Xenopus tropicalis

Alignment Length:	316	Identity:	61/316 - (19%)
Similarity:	104/316 - (32%)	Gaps:	90/316 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 TGNTIVLKPA----------------EQTSLTAL------YI-----AQLVKEAGFPEGVVNVVP 242
            |||..|..|.                |.||:.|:      |:     .:.:|:.|.....|..:.
Frog   107 TGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPYLQTRHRVEQLKQLGHSVDKVEFIV 171

  Fly   243 GFGTAGAALANHCDV------DKVAFTGSTDVGKLIQLAS-GNTNLKRVTLELGGKSPNIILSDT 300
            ..||..|...::.|.      |.::...|..|.:.::.:. .||....:|:|            |
Frog   172 MGGTFMALSEDYRDFFIRNLHDALSGHTSNSVSEAVRYSERSNTKCVGITIE------------T 224

  Fly   301 DMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKK-RTVGNPFDLNTEQGPQV 364
            ..||.:: .|.....:.|   |......|: .:|:: |.|...|... :.|...|.:..:.|.:|
Frog   225 RPDYCLK-RHLSDMLSYG---CTRLEIGVQ-SVYED-VARDTNRGHTVKAVCESFHMAKDAGFKV 283

  Fly   365 NEEQMEKILGM-IKTGKKQGAKLVAGGS-RPEGLPGY--------------------FVQPTVFA 407
            ....|..:..: ::...:|..:.....: ||:|:..|                    ...|:...
Frog   284 VSHMMPDLPNVGLERDTEQFIEFFENPAFRPDGMKLYPTLVIRGTGLYELWKTGRYRSYSPSTLV 348

  Fly   408 DVQDDMTIAREEIFGP-------VQQLIRFKKLDEVIERANNSEYGLAAAVFTKDL 456
            |:     :||.....|       ||:.|....:...:|..|..|..||.   .|||
Frog   349 DL-----VARILALVPPWTRVYRVQRDIPMPLVSSGVEHGNLRELALAR---MKDL 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	61/316 (19%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	61/316 (19%)
elp3	NP_001001215.1	ELP3	39..548	CDD:273503	61/316 (19%)
		Acetyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:A0A1C7D1B7	476..479
		Acetyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:A0A1C7D1B7	499..501
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900