DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and Aldh7A1

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	150/540 - (27%)
Similarity:	250/540 - (46%)	Gaps:	54/540 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ALLRSQAK-----NFAAAVANYSS-----LPQPQ-----------TTPDILYTGVFINNEWHKSK 52
            |.||:.:|     ......|:|||     :.||:           ..|.: |:|     :|  ..
  Fly     3 AQLRNISKLALPRRLVTQTASYSSSSSYLIDQPEYSFLKELGLERDNPGV-YSG-----QW--QG 59

  Fly    53 SGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERGRLLYRLADLMER 117
            .|....:.:|.|.:.||:::..:.::::..:..|..|:|   .||::.|..||.::.::.|.:.:
  Fly    60 RGPSVTSYDPGTGQPIAKVRQGNVQELEHTIGLAVEAYK---QWRQVPAPVRGEIVRQIGDELRK 121

  Fly   118 DQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTIPMD-GDFFTYTRHEPVGV 181
            .:..|..|.:|:.||.||.... ::...|....|..|.:....|:.|..: .|........|:||
  Fly   122 YKEPLGKLVSLEVGKIYSEGQG-EVQEFIDICDYAVGLSRIYSGQLINSERADHSILEAWRPLGV 185

  Fly   182 CGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSL----TALYIAQLVKEAGFPEGVVNVVP 242
            .|.|..:|||..:..|....||.|||:::.|.|..|.|    |...:|::::....|. ||.:..
  Fly   186 VGVISAYNFPNAVFGWNAAIALTTGNSVLWKGAPSTPLVSVATTKIVAEVLRRNNLPP-VVTLCQ 249

  Fly   243 GFGTAGAALANHCDVDKVAFTGS----TDVGKLIQLASGNTNLKRVTLELGGKSPNIILSDTDMD 303
            |....|..|.....|:.|:||||    .|||..:|...|     :|.|||||.:..||....::.
  Fly   250 GGTDVGQTLVADKRVNLVSFTGSCQTGRDVGVEVQRRFG-----KVILELGGNNALIIDESANVK 309

  Fly   304 YAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKK--RTVGNPFDLNTEQGPQVNE 366
            .|::.|.||.....||.|....|..|.:|::|:||:....:.|:  ..:|:..:..|..||...:
  Fly   310 MALDAALFGCIGTSGQRCTTTRRIIVHEKLHDQFVKELVGKYKQLISKIGHQLEAQTLVGPVHTQ 374

  Fly   367 EQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTIAREEIFGPVQQLIRFK 431
            :.:|.....|...|..|..:..||:..: ..|::|:|||...:..|.::...|.|.|:..:::.|
  Fly   375 QNVENYKAAIAEAKSLGGTVAFGGNVIQ-RDGFYVEPTVITGLPHDASVVHRETFAPIVYILKAK 438

  Fly   432 KLDEVIERANNSEYGLAAAVFTKDLDKANYIVG--GLRAGTVWVN-TYNVLAAQAPFGGYKMSGH 493
            .:|:.||..|..|.||::|:||:::.:|...:|  |...|.|.:| |.|.......|||.|.:|.
  Fly   439 NVDQAIEWNNEVEQGLSSAIFTENIGQAFKWIGAKGSDCGIVNINTTTNGAEIGGAFGGEKATGG 503

  Fly   494 GRENGEYALSNYTEVKSVIV 513
            |||:|..|...|.:..::.|
  Fly   504 GRESGSDAWKQYCKRATITV 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	149/537 (28%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	140/494 (28%)
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	139/492 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454091
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740