DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and aldh9a1b

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_009295330.1	Gene:	aldh9a1b / 399481	ZFINID:	ZDB-GENE-040120-5	Length:	539	Species:	Danio rerio

Alignment Length:	513	Identity:	195/513 - (38%)
Similarity:	305/513 - (59%)	Gaps:	26/513 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 YSSLPQPQT-----------TPDILYTGVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKED 78
            |.:|..|.|           .|...:.|..::.:..|:||..:||   |.|..|:..:|.....:
Zfish    34 YRTLYHPWTRCASSGTLQIKDPLNFWCGARVDLKDVKTKSEPVFE---PATGRVLCRLQTCGSAE 95

  Fly    79 IDIAVQAARNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLP 143
            :|.||:.|..|||:   ||::...||.|::...|.|:|:.:..:|.:|.::|||..:.: .:|:.
Zfish    96 VDAAVRNASAAFKV---WRKLSGMERARVMLEAARLIEKRREEIAEMEVINNGKSITEA-RLDVD 156

  Fly   144 TAIKNLRYFAGWADKNHGKTIPMDGDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNT 208
            :|..::.||||.|....|:.:.:.|..|.|||.||.|||..|..||:|..:.|||..||:|.||:
Zfish   157 SARLSIEYFAGQATTLSGQHVQLPGGSFAYTRREPFGVCVGIGAWNYPFQIAAWKSAPAIACGNS 221

  Fly   209 IVLKPAEQTSLTALYIAQLVKEAGFPEGVVNVVPGFGTAGAALANHCDVDKVAFTGSTDVG-KLI 272
            :|.||:..|.:||:.:|::.::||.|||:.|||.|....|:.|..|..|:||:||||...| |::
Zfish   222 MVFKPSPLTPVTAVLLAEIYRQAGAPEGLFNVVQGGQETGSLLCLHPSVEKVSFTGSVPTGKKIM 286

  Fly   273 QLASGNTNLKRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEF 337
            ::||  ..:|.||||||||||.||..|||::.||..|....|.:.||.|..|:|.||:..|..:|
Zfish   287 EMAS--RGVKAVTLELGGKSPLIIFEDTDLENAVRGALMANFLSQGQVCSNGTRVFVQSSIVPQF 349

  Fly   338 VERSAERAKKRTVGNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGG-----SRPEGLP 397
            ::....|.|..::|:|....|..|..|::..::|:|..::..|.:||:::.||     :.|:...
Zfish   350 LKEVVRRTKAISIGDPLLDETRMGALVSKAHLDKVLRYVEQAKNEGAQVLCGGEPFSPADPKLKD 414

  Fly   398 GYFVQPTVFADVQDDMTIAREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYI 462
            ||::.|.|.....||||..:|||||||..::.|...|||:.|||:|:.||||.|||||:.:|:.:
Zfish   415 GYYMTPCVLDSCTDDMTCVKEEIFGPVMSVLTFDTEDEVLRRANDSDLGLAAGVFTKDVKRAHRV 479

  Fly   463 VGGLRAGTVWVNTYNVLAAQAPFGGYKMSGHGRENGEYALSNYTEVKSVIVKVAQKNS 520
            :..|:||:.::|.||:...:.||||:|.||.|||||:..:..|:::|:|:|::...:|
Zfish   480 IENLQAGSCFINNYNITPVEVPFGGFKASGIGRENGQVTIEFYSQLKTVVVEMGDVDS 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	192/503 (38%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	189/485 (39%)
aldh9a1b	XP_009295330.1	ALDH_F9_TMBADH	76..533	CDD:143409	185/465 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810