DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and CG6661

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_648686.3	Gene:	CG6661 / 39556	FlyBaseID:	FBgn0036403	Length:	581	Species:	Drosophila melanogaster

Alignment Length:	482	Identity:	116/482 - (24%)
Similarity:	201/482 - (41%)	Gaps:	77/482 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 IAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLASL------E 126
            :|.:..|:::.|:.|:::|.:|   ...|..:..::|..:..|.|.::|.|::.|...      :
  Fly   112 LAHVYYANRKQIEAAIKSALSA---QGTWSLVPIAQRLAIWRRAATIIEEDELRLRVFLMMTLSK 173

  Fly   127 TLDNGKP------YSMSYNVDLPTAIKNLRYFAGWADKN-----HGKTIPMDGDFFTYTRHEPVG 180
            |.|:...      .|:..|.|....:..|| |....|.|     |.:  |||            |
  Fly   174 TADDATRDIRRLLTSLRANADYLEHLSELR-FEIQGDMNVFPSFHLR--PMD------------G 223

  Fly   181 VCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTALYIAQLVKEAGFPEGVVNVVPGFG 245
            ....:.|:....|..:..|.||| .|||::..|:.:.:..:..|.:..:|||.|.||:|.||
  Fly   224 FVAALAPFESVALSSSLALCPAL-MGNTVLWNPSLEVAPVSYLIFRAFQEAGLPSGVINFVP--- 284

  Fly   246 TAGAALANHCDVDKVAFTG-STDVGKLI-----QLASGNTN----LKRVTLELGGKSPNIILSDT 300
             |...|......|.|.|.| :|......     :|.|....    ..|:..|..|::.:.:.:..
  Fly   285 -ANERLFLDTITDAVHFAGLNTQASAAFYRHVHKLVSDRMERYICFPRLVAECPGQNFHFVHASA 348

  Fly   301 DMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVGNPFDLNTEQGPQV- 364
            .::..|.......|...||...:.||.:|...::....|...|..::.|:|:|.:..|:.|..|
  Fly   349 KVESVVSATVQAAFGFAGQYANSLSRMYVPSSMWPRLREELVEATEQLTIGDPIESETDIGAMVH 413

  Fly   365 -NE-EQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPTVFADVQDDM-TIAREEIFGPVQQ 426
             |: .:|:|:|...|..::     :.|||..:. .|.||.||: ..|.|.: .:..|...||...
  Fly   414 INDFRRMQKLLQRTKNMEQ-----LCGGSCDDS-TGRFVDPTI-VRVSDPLDPLLCEPCCGPFLP 471

  Fly   427 LIRFK--KLDEVIE-RANNSEYGLAAAVFTKDLDKANYIVGGLR--AGTVWVN------TYNVLA 480
            :..:.  ...|.:: .||.|.|.|:.::|....:...:.:..||  |..::||      ||.:
  Fly   472 VFVYSDDSFSEALKLAANQSRYALSGSIFASQDEVILHCLNQLRMSASNLYVNERCTGSTYGL-- 534

  Fly   481 AQAPFGGYKMSGHGRENGE-YALSNYT 506
              .||||.::||...::|. |.|..::
  Fly   535 --TPFGGNRLSGTNDKSGSAYFLMRWS 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	116/482 (24%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	116/482 (24%)
CG6661	NP_648686.3	ALDH-SF	68..567	CDD:299846	116/482 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454100
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740