DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and aldh4a1

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_957452.1	Gene:	aldh4a1 / 394133	ZFINID:	ZDB-GENE-040426-1179	Length:	556	Species:	Danio rerio

Alignment Length:	495	Identity:	131/495 - (26%)
Similarity:	229/495 - (46%)	Gaps:	42/495 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 INNE--WHKSKSGKIFETINP-TTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERG 105
            |.||  |.|.    |...::| ..:..:|:...|||:.::.|::|:..|.:   .|.....|:|.
Zfish    61 IGNEEVWTKD----IRFQLSPFNHSHQVAKFCYADKDLLNKAIEASVAARR---EWDLKPVSDRA 118

  Fly   106 RLLYRLADLM---ERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTIPMD 167
            ::.::.||::   :|.:|...::  :..||....:.....|..|...|:.|..|.:...:. |:|
Zfish   119 QIFFKAADIISGPKRAEVLAKTM--IGQGKTVVQAEIDAAPELIDFFRFNAKHAIELEDQQ-PLD 180

  Fly   168 GDFFTYTR--HEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTALY-IAQLVK 229
            .|..|.|.  ....|....:.|:||..:.......||| .||.::.||:: |:::|.| :.::::
Zfish   181 SDGSTNTMLYRGLEGFVAAVAPFNFTAIGGNLAGTPAL-MGNVVLWKPSD-TAMSASYAVYKILR 243

  Fly   230 EAGFPEGVVNVVPGFGTA-GAALANHCDVDKVAFTGSTDVGKLI--QLASG---NTNLKRVTLEL 288
            |:|.|..::..||..|.. |..:.:...:..:.||||....|.:  |:|..   ..|..||..|.
Zfish   244 ESGLPPNIIQFVPADGPVFGDTVTSSEHLAGINFTGSVPTFKRLWKQVAQNLDIYKNFPRVAGEC 308

  Fly   289 GGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVGNP 353
            |||:.:.:....|:...|.......|...||.|.|.||.:|.|.::.:..:...:..|:..||:|
Zfish   309 GGKNFHFVHKSADVRSVVTGTIRSAFEYGGQKCSACSRMYVPDSLWPQIRQGLLDVYKQIKVGDP 373

  Fly   354 F-DLNTEQGPQVNEEQMEKILGMIKTGKKQ-GAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTIA 416
            . |.:|.....::::...:|.|.::..:.. ..|::|||: .:...||||:||:.........|.
Zfish   374 VEDFSTFFSAVIDDKSFSRIKGWLEHARSSPHLKIIAGGN-CDDKKGYFVEPTIIETTDPQEKIM 437

  Fly   417 REEIFGPVQQLI-----RFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLR--AGTVWVN 474
            .|||||||..:.     .:||:..:|:  |.|.|.|..|:|.:|..........||  ||..::|
Zfish   438 NEEIFGPVLTVYVYPENDYKKVLHLID--NTSPYALTGAIFPQDKSVIEEAGKALRNAAGNYYIN 500

  Fly   475 TYNV--LAAQAPFGGYKMSG-HGRENGEYALSNYTEVKSV 511
            ..:.  :.||.||||.:.|| :.:..|.:.:..:|..:.|
Zfish   501 DKSTGSIVAQQPFGGARASGTNDKPGGPHYVLRWTSPQVV 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	131/495 (26%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	131/495 (26%)
aldh4a1	NP_957452.1	ALDH_F4-17_P5CDH	25..546	CDD:143441	131/495 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910