DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and aldh2.1

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_956784.1	Gene:	aldh2.1 / 393462	ZFINID:	ZDB-GENE-040426-1262	Length:	516	Species:	Danio rerio

Alignment Length:	521	Identity:	360/521 - (69%)
Similarity:	423/521 - (81%)	Gaps:	6/521 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLRVLKTGALLRSQAKNFAAAVANYSSLPQPQTTPDILYTGVFINNEWHKSKSGKIFETINPTTA 65
            |||.:    ..|:..:.|..:...:|::|.|...||:.|..:|||||||.:.|.|.|.||||.||
Zfish     1 MLRTV----FSRTFPQVFRISSCQHSTIPAPNVQPDVHYNKIFINNEWHDAVSKKTFPTINPATA 61

  Fly    66 EVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDN 130
            |||..:...||.|:|.||:|||:||||||||||||||:||.||.||||.:|||..|||.||||||
Zfish    62 EVICHVAEGDKADVDKAVKAARDAFKLGSPWRRMDASQRGLLLNRLADCIERDAAYLAELETLDN 126

  Fly   131 GKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTIPMDGDFFTYTRHEPVGVCGQIIPWNFPILMM 195
            ||||::|:.||||..:|.|||:||||||..|||||:||::|.||||||:||||||||||||:||.
Zfish   127 GKPYTLSFCVDLPMVVKCLRYYAGWADKWEGKTIPIDGNYFCYTRHEPIGVCGQIIPWNFPLLMQ 191

  Fly   196 AWKLGPALATGNTIVLKPAEQTSLTALYIAQLVKEAGFPEGVVNVVPGFG-TAGAALANHCDVDK 259
            |.|||||||||||:|:|.||||.|||||||.|:||.|||.||||:||||| |||||:|:|.||||
Zfish   192 ALKLGPALATGNTVVMKVAEQTPLTALYIASLIKEVGFPAGVVNIVPGFGPTAGAAIASHMDVDK 256

  Fly   260 VAFTGSTDVGKLIQLASGNTNLKRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAG 324
            ||||||||||.|||.||..:|||.|:||||||||||||||.:|:.|||.||..||||.|||||||
Zfish   257 VAFTGSTDVGHLIQQASSASNLKNVSLELGGKSPNIILSDANMEEAVEQAHSALFFNQGQCCCAG 321

  Fly   325 SRTFVEDKIYDEFVERSAERAKKRTVGNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAG 389
            :||||::.|||||||||.||||.|.||:||||||||||||:|:|.:|:||.|.:||::||||:.|
Zfish   322 TRTFVQESIYDEFVERSVERAKNRIVGDPFDLNTEQGPQVDEDQFKKVLGYISSGKREGAKLMCG 386

  Fly   390 GSRPEGLPGYFVQPTVFADVQDDMTIAREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTK 454
            |: |....|||:|||||.||:||||||||||||||.|:::||.|:|||||||:|:|||||||||:
Zfish   387 GA-PAAERGYFIQPTVFGDVKDDMTIAREEIFGPVMQILKFKSLEEVIERANDSKYGLAAAVFTQ 450

  Fly   455 DLDKANYIVGGLRAGTVWVNTYNVLAAQAPFGGYKMSGHGRENGEYALSNYTEVKSVIVKVAQKN 519
            ::||||||..||||||||:|.|||...||||||||.||.|||.|||.|..|||||:|.:||.|||
Zfish   451 NIDKANYISHGLRAGTVWINCYNVFGVQAPFGGYKASGIGRELGEYGLDIYTEVKTVTIKVPQKN 515

  Fly   520 S 520
            |
Zfish   516 S 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	350/503 (70%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	346/480 (72%)
aldh2.1	NP_956784.1	ALDH_F1AB_F2_RALDH1	30..510	CDD:143459	346/480 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596137
Domainoid	1	1.000	693	1.000	Domainoid score	I126
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55480
Inparanoid	1	1.050	735	1.000	Inparanoid score	I592
OMA	1	1.010	-	-		QHG53964
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	1	1.000	-	-		otm25487
orthoMCL	1	0.900	-	-		OOG6_100163
Panther	1	1.100	-	-	O	PTHR11699
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2025
SonicParanoid	1	1.000	-	-		X158
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800