DRSC/TRiP Functional Genomics Resources

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Protein Alignment Aldh and aldh2.2

DIOPT Version :9

Sequence 1:NP_001260290.1 Gene:Aldh / 34256 FlyBaseID:FBgn0012036 Length:520 Species:Drosophila melanogaster
Sequence 2:NP_998466.2 Gene:aldh2.2 / 368239 ZFINID:ZDB-GENE-030326-5 Length:516 Species:Danio rerio


Alignment Length:521 Identity:357/521 - (68%)
Similarity:424/521 - (81%) Gaps:6/521 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MLRVLKTGALLRSQAKNFAAAVANYSSLPQPQTTPDILYTGVFINNEWHKSKSGKIFETINPTTA 65
            |||.:    |.|:..:....:...:|::|.|...||:.|..:|||||||.:.|.|.|.||||.|.
Zfish     1 MLRTV----LSRAFPQVCRISSCQHSTIPAPNVQPDVHYNKIFINNEWHDAVSKKTFPTINPATG 61

  Fly    66 EVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDN 130
            |:|..:...||.|:|.||:|||:||||||||||||||:||.||.||||.:|||..|||.||||||
Zfish    62 EIICHVAEGDKADVDKAVKAARDAFKLGSPWRRMDASQRGLLLSRLADCIERDAAYLAELETLDN 126

  Fly   131 GKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTIPMDGDFFTYTRHEPVGVCGQIIPWNFPILMM 195
            ||||::|::||:|..:|.:||:||||||..|||||:||::|.||||||:||||||||||||:||.
Zfish   127 GKPYAVSFSVDVPMVVKCMRYYAGWADKWEGKTIPIDGNYFCYTRHEPIGVCGQIIPWNFPLLMQ 191

  Fly   196 AWKLGPALATGNTIVLKPAEQTSLTALYIAQLVKEAGFPEGVVNVVPGFG-TAGAALANHCDVDK 259
            |||||||||||||:|:|.||||.|||||||.|:||.|||.||||:|||.| |||||:|:|.||||
Zfish   192 AWKLGPALATGNTVVMKVAEQTPLTALYIASLIKEVGFPAGVVNIVPGMGPTAGAAIASHMDVDK 256

  Fly   260 VAFTGSTDVGKLIQLASGNTNLKRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAG 324
            ||||||||||.|||.||..:|||:||||||||||||||||.:|:.|||.:|..||||.|||||||
Zfish   257 VAFTGSTDVGHLIQRASSASNLKKVTLELGGKSPNIILSDANMEEAVEQSHIALFFNQGQCCCAG 321

  Fly   325 SRTFVEDKIYDEFVERSAERAKKRTVGNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAG 389
            :||||::.|||||||||.||||.|.||:||||||||||||||:|.:|:||.|.:||::||||:.|
Zfish   322 TRTFVQESIYDEFVERSVERAKNRIVGDPFDLNTEQGPQVNEDQFKKVLGYISSGKREGAKLMCG 386

  Fly   390 GSRPEGLPGYFVQPTVFADVQDDMTIAREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTK 454
            |: |....|||:|||||.||:||||||||||||||.|:::||.|:|||||||:|:||||.||||:
Zfish   387 GA-PAAERGYFIQPTVFGDVKDDMTIAREEIFGPVMQILKFKSLEEVIERANDSKYGLAGAVFTQ 450

  Fly   455 DLDKANYIVGGLRAGTVWVNTYNVLAAQAPFGGYKMSGHGRENGEYALSNYTEVKSVIVKVAQKN 519
            |:||||||..||||||||:|.|||...||||||||.||.|||.|||.|.||||||:|.:||.:||
Zfish   451 DIDKANYISHGLRAGTVWINCYNVFGVQAPFGGYKASGIGREMGEYGLENYTEVKTVTIKVPEKN 515

  Fly   520 S 520
            |
Zfish   516 S 516

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AldhNP_001260290.1 PLN02466 9..512 CDD:215259 348/503 (69%)
ALDH_F1AB_F2_RALDH1 34..514 CDD:143459 344/480 (72%)
aldh2.2NP_998466.2 ALDH_F1AB_F2_RALDH1 30..510 CDD:143459 344/480 (72%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170596138
Domainoid 1 1.000 693 1.000 Domainoid score I126
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H55480
Inparanoid 1 1.050 735 1.000 Inparanoid score I592
OMA 1 1.010 - - QHG53964
OrthoDB 1 1.010 - - D153834at2759
OrthoFinder 1 1.000 - - FOG0000158
OrthoInspector 1 1.000 - - otm25487
orthoMCL 1 0.900 - - OOG6_100163
Panther 1 1.100 - - LDO PTHR11699
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2025
SonicParanoid 1 1.000 - - X158
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1413.940

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