DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and Aldh16a1

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001028878.1	Gene:	Aldh16a1 / 361571	RGDID:	1566295	Length:	802	Species:	Rattus norvegicus

Alignment Length:	466	Identity:	142/466 - (30%)
Similarity:	226/466 - (48%)	Gaps:	30/466 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 GVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERG 105
            |.::|..|.|.:........:|.|.|.:|....|:.|||..||:|||..||   .|.::..:.||
  Rat    41 GHYVNGMWLKPEHRNPAPCQDPITGENLASCLQAEAEDISAAVEAARITFK---TWSQLPGTARG 102

  Fly   106 RLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTIPMDGDF 170
            :.|.|||.::::.|..|.:||:|..|:......:.|:|.|.:.|.|.|..|   |.:...: .|:
  Rat   103 QHLTRLAKVIQKHQRLLWTLESLVTGRAVREVRDGDIPLAQQLLHYHALQA---HAQDSAL-ADW 163

  Fly   171 FTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIV-LKPAEQTSLTALYIAQLVKEAGFP 234
                  ||:||.|.|:|.:|..|.|.|::.||||.|.|:| |.|  .:..|.|.:|||..|.|..
  Rat   164 ------EPLGVIGLILPTSFSFLDMMWRVCPALAMGCTVVALVP--PSFPTPLLLAQLAGELGSF 220

  Fly   235 EGVVNVVPGFGTAGAALANHCDVDKVAFTGSTDVGKLIQ--LASGNTNLKRVTLELGGKSPNIIL 297
            .|::|||.|..:.|..||:...|.||||.|:.:.|:.::  ||.....|   .|.||.:|..::.
  Rat   221 PGILNVVCGPVSLGPVLASQPGVQKVAFCGAVEEGRALRQTLAGRGATL---GLALGTESLLLLT 282

  Fly   298 SDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVGNPFDLNTEQGP 362
            ...|:|.|||.....::.:..   ..|.|..:::.::||.::|...|..:...|...|...:.|.
  Rat   283 DSADVDSAVEGVVDAVWSDRS---LGGLRLLIQESVWDEAMKRLQARMAQIRSGKGLDGAVDMGA 344

  Fly   363 QVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTIAREEIFGPVQQL 427
            : .....:.....:...:.||.::...|..|...|  |..||:.:.:......|:.|:..||...
  Rat   345 R-GAAARDLAQSFVDEAQSQGGQVFQAGDMPSNSP--FFSPTLVSGLPPAAPCAQAEVPWPVVMA 406

  Fly   428 IRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLAAQAPFGGYKMSG 492
            ..|:.:.|.:..||.:..|.:|:|:::.|.:|..:..||:.||||:|.:.:.....|.||.|.||
  Rat   407 SPFRTVKEALALANGTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPAVPTGGCKESG 471

  Fly   493 ---HGRENGEY 500
               ||..:|.|
  Rat   472 SSWHGGPDGLY 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	142/466 (30%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	142/466 (30%)
Aldh16a1	NP_001028878.1	ALDH-SF	19..491	CDD:416387	142/466 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..554
		ALDH-SF	550..>765	CDD:416387
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810