DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and P5CDh2

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_788705.1	Gene:	P5CDh2 / 32625	FlyBaseID:	FBgn0053092	Length:	614	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	126/534 - (23%)
Similarity:	219/534 - (41%)	Gaps:	103/534 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VFINNEWHKSKSGKIFETINP-TTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERG 105
            :.||.:..::|..  |:.:.| ...:.||....|.:..|.:|:..:..|   ...|.::..|:|
  Fly    84 IVINGQEFQAKED--FQQVLPYDIQQPIAHYGHAHRVLIQMAIDKSVEA---QVKWDKVRLSDR- 142

  Fly   106 RLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTI---PMD 167
                  .|:.||..:.:|.          ...||:...|.:            ..|||:   .||
  Fly   143 ------IDIWERAAMLIAG----------RYRYNIIAATML------------GQGKTLRQAEMD 179

  Fly   168 -GDFFTYTRHEPV----------------------------GVCGQIIPWNFPILMMAWKLGPAL 203
             .:...:.|..||                            |....|.|:||..:.......|||
  Fly   180 VAELVDFMRINPVFLRELANYEPIRDIQNNCRNSMRLRGLSGFVAAISPFNFTGIAANLAYTPAL 244

  Fly   204 ATGNTIVLKPAEQTSLTALYIAQLVKEAGFPEGVVNVVPGFGTAGAA-LANHCDVDKVAFTGSTD 267
             .||:::.||::...|:..::.:.::|||.|:||||.||...|..|: :..|..:..:.|||::.
  Fly   245 -MGNSVIWKPSDSAILSNYFVFKALREAGVPDGVVNFVPAEETTFASVVTQHPKLAGINFTGTST 308

  Fly   268 VGKLI-QLASGNTNL----KRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRT 327
            |.|:: ||.:.|.|.    .|:..|.|||:.:.:.|..:.:.||.......|...||.|.:.|..
  Fly   309 VLKVLWQLVAQNINFYQNYPRLVGEGGGKNFHFVHSSAEPETAVACTIRAAFEYAGQKCSSCSML 373

  Fly   328 FVEDKIY-----DEFVERSAERAKKR--TVGNPFDLNTEQGPQVNEEQMEKILGMIK-TGKKQGA 384
            :|.:.::     :..:|.:|....::  |..:.|     ....:|....::|...:: ..:....
  Fly   374 YVPESLWQNHIREPLLEITASLVVRQDATYCDSF-----CSAVINRRAYDRIYMWLRYIDQSPSC 433

  Fly   385 KLVAGGSRPEGLPGYFVQPTVFADVQDDMTIAREEIFGPVQQLIRF--KKLDEVIERANNSEYGL 447
            :::.||| .:...||:|.|||......|..|.|||:..|:..:..:  .||.|.:|:.....:||
  Fly   434 QILVGGS-CDKRRGYYVDPTVVLVKDLDNIICREELLAPILGVYVYPDHKLKETMEKVAQINHGL 497

  Fly   448 AAAVFTKDLDKANYIVGGLRAGTVWVNTYNV-------LAAQAPFGGYKMSGHGRENG-EYALSN 504
            ..:||.:|   .|:|.....|..|.|...||       :..|.|||...|:|...:.| .::|..
  Fly   498 TGSVFAQD---QNFIEEAYDAFRVNVGNLNVNDKSTGLMVGQQPFGAGHMTGTSDKLGTPHSLLR 559

  Fly   505 YTEVKSVIVKVAQK 518
            :|..:  ::|.:.|
  Fly   560 WTSPQ--VIKESYK 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	124/526 (24%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	124/528 (23%)
P5CDh2	NP_788705.1	ALDH-SF	50..570	CDD:299846	125/531 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454102
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740