DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and Aldh3b1

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001006999.1	Gene:	Aldh3b1 / 309147	RGDID:	1359546	Length:	468	Species:	Rattus norvegicus

Alignment Length:	444	Identity:	124/444 - (27%)
Similarity:	202/444 - (45%)	Gaps:	32/444 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 VQAARNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDNGKPYSMS---------Y 138
            :|..|.||..|   |...|..|...|..|:..:..::..|......|..|....|         .
  Rat     8 LQQLREAFNAG---RTRSAEFRAAQLQGLSHFLRDNKQQLQEALAQDLHKSAFESEVSEIAISQA 69

  Fly   139 NVDLPTAIKNLRYFAGW-ADKNHGKTIPMDGDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPA 202
            .|||  |::|||   .| .|:...|.:....| ..:.|.||.|:...|:|||:|:.:....|..|
  Rat    70 EVDL--ALRNLR---SWMKDEKVSKNLATQLD-SAFIRKEPFGLVLIIVPWNYPLNLTLVPLVGA 128

  Fly   203 LATGNTIVLKPAEQTSLTALYIAQLVKEAGFPEGVVNVVPGFGTAGAALANHCDVDKVAFTGSTD 267
            :|.||.:||||:|.:..|...:|:::... ..:....||.|.......|..| ..|.:.|||:|.
  Rat   129 IAAGNCVVLKPSEISKATEKILAEVLPRY-LDQSCFAVVLGGPQETGQLLEH-RFDYIFFTGNTY 191

  Fly   268 VGKLIQLASGNTNLKRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDK 332
            |||:: :|:...:|..:|||||||:|..:..:.|.........:..:||.||.|.|........:
  Rat   192 VGKIV-MAAAAKHLTPITLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSQE 255

  Fly   333 IYDEFVERSAERAKKRTVGNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLP 397
            :.:..|. :.:.|..|..|:....:...|..:|::..|::.|::..|     ::..||...||
  Rat   256 MQERLVP-ALQNAITRFYGDNPQTSPNLGRIINQKHFERLQGLLGCG-----RVAIGGQSDEG-- 312

  Fly   398 GYFVQPTVFADVQDDMTIAREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYI 462
            ..::.|||..|||:...:.:||||||:..|:....|||.||..|..|..||...|:|.......:
  Rat   313 ERYIAPTVLVDVQETEPVMQEEIFGPILPLVTVTNLDEAIEFINRREKPLALYAFSKRSQVIKQV 377

  Fly   463 VGGLRAGTVWVNT--YNVLAAQAPFGGYKMSGHGRENGEYALSNYTEVKSVIVK 514
            :....:|....|.  .::..:..||||...||.||.:|:::...::..::.:::
  Rat   378 LARTSSGGFCGNDGFMHMTLSSLPFGGVGTSGMGRYHGKFSFDTFSNQRACLLR 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	124/440 (28%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	124/442 (28%)
Aldh3b1	NP_001006999.1	ALDH_F3AB	5..447	CDD:143450	124/444 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810