DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and Aldh1b1

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001011975.1	Gene:	Aldh1b1 / 298079	RGDID:	1306737	Length:	519	Species:	Rattus norvegicus

Alignment Length:	511	Identity:	344/511 - (67%)
Similarity:	417/511 - (81%)	Gaps:	6/511 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LRSQAKNFAAAVANYSSLPQPQTTPDILYTGVFINNEWHKSKSGKIFETINPTTAEVIAEIQCAD 75
            |:.:..:::.|.|    ||.|...|:|.|..:|||||||.:.|.|.|.|:||||.|||..:...|
  Rat    14 LQGRTTSYSTAAA----LPNPIPNPEIRYNQLFINNEWHDAVSKKTFPTVNPTTGEVIGHVAEGD 74

  Fly    76 KEDIDIAVQAARNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNV 140
            :.|:|:||:|||.||:|||||||||||||||||.|||||:|||:||||||||||||||:..||.:
  Rat    75 RADVDLAVRAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLASLETLDNGKPFQESYVL 139

  Fly   141 DLPTAIKNLRYFAGWADKNHGKTIPMDGDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALAT 205
            ||...||..||.||||||.|||||||||:.|.:||||||||||||||||||::|..|||.|||||
  Rat   140 DLDEVIKVYRYLAGWADKWHGKTIPMDGEHFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALAT 204

  Fly   206 GNTIVLKPAEQTSLTALYIAQLVKEAGFPEGVVNVVPGFG-TAGAALANHCDVDKVAFTGSTDVG 269
            |||:|:|.||||.|:|||:|.|:||||||.||||::.|:| |||||:|.|.|||||||||||:||
  Rat   205 GNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHMDVDKVAFTGSTEVG 269

  Fly   270 KLIQLASGNTNLKRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIY 334
            .|||.|:|::||||||||||||||:|:|:|.|||:||:..|..||||||||||||||||||:.||
  Rat   270 HLIQKAAGDSNLKRVTLELGGKSPSIVLADADMDHAVDQCHEALFFNMGQCCCAGSRTFVEESIY 334

  Fly   335 DEFVERSAERAKKRTVGNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGY 399
            .||:||:.|:||||.|||||:|:|:|||||::||.|||||.|:.|:|:||||:.||.| .|..|:
  Rat   335 HEFLERTVEKAKKRKVGNPFELDTQQGPQVDKEQFEKILGYIRLGQKEGAKLLCGGER-FGERGF 398

  Fly   400 FVQPTVFADVQDDMTIAREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVG 464
            |::||||.:|||||.|||||||||||.|.:|||::|||:||||:.|||||||||:|||||.|...
  Rat   399 FIKPTVFGNVQDDMRIAREEIFGPVQPLFKFKKIEEVIQRANNTRYGLAAAVFTRDLDKALYFSQ 463

  Fly   465 GLRAGTVWVNTYNVLAAQAPFGGYKMSGHGRENGEYALSNYTEVKSVIVKVAQKNS 520
            .|:||||||||||::....||||:|.||:|||.||..|..|||||:|.:||::|||
  Rat   464 ALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGEDGLKAYTEVKTVTIKVSEKNS 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	338/501 (67%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	333/480 (69%)
Aldh1b1	NP_001011975.1	PLN02466	13..510	CDD:215259	338/500 (68%)
Aldh1b1	NP_001011975.1	ALDH_F1AB_F2_RALDH1	33..513	CDD:143459	333/480 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	699	1.000	Domainoid score	I117
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	737	1.000	Inparanoid score	I568
OMA	1	1.010	-	-		QHG53964
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	1	1.000	-	-		otm45781
orthoMCL	1	0.900	-	-		OOG6_100163
Panther	1	1.100	-	-	O	PTHR11699
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X158
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840