DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and Aldh2

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_115792.2	Gene:	Aldh2 / 29539	RGDID:	69219	Length:	519	Species:	Rattus norvegicus

Alignment Length:	521	Identity:	361/521 - (69%)
Similarity:	428/521 - (82%)	Gaps:	3/521 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLRVLKTGALLRSQAKNFAAAVANYSSLPQPQTTPDILYTGVFINNEWHKSKSGKIFETINPTTA 65
            |||...:.|....:.....:|.|. |::|.|...|::....:|||||||.:.|.|.|.|:||:|.
  Rat     1 MLRAALSTARRGPRLSRLLSAAAT-SAVPAPNQQPEVFCNQIFINNEWHDAVSKKTFPTVNPSTG 64

  Fly    66 EVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDN 130
            |||.::...:|||:|.||:|||.||:|||||||||||:|||||||||||:|||:.|||:||||||
  Rat    65 EVICQVAEGNKEDVDKAVKAARAAFQLGSPWRRMDASDRGRLLYRLADLIERDRTYLAALETLDN 129

  Fly   131 GKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTIPMDGDFFTYTRHEPVGVCGQIIPWNFPILMM 195
            ||||.:||.|||...:|.|||:||||||.||||||:|||||:|||||||||||||||||||:||.
  Rat   130 GKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQ 194

  Fly   196 AWKLGPALATGNTIVLKPAEQTSLTALYIAQLVKEAGFPEGVVNVVPGFG-TAGAALANHCDVDK 259
            ||||||||||||.:|:|.||||.|||||:|.|:||||||.||||:||||| |||||:|:|.||||
  Rat   195 AWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDK 259

  Fly   260 VAFTGSTDVGKLIQLASGNTNLKRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAG 324
            |||||||:||.|||:|:|::|||||||||||||||||:||.|||:|||.|||.||||.|||||||
  Rat   260 VAFTGSTEVGHLIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAG 324

  Fly   325 SRTFVEDKIYDEFVERSAERAKKRTVGNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAG 389
            |||||::.:||||||||..|||.|.||||||..|||||||:|.|.:||||.||:|:::||||:.|
  Rat   325 SRTFVQEDVYDEFVERSVARAKSRVVGNPFDSRTEQGPQVDETQFKKILGYIKSGQQEGAKLLCG 389

  Fly   390 GSRPEGLPGYFVQPTVFADVQDDMTIAREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTK 454
            |..... .|||:|||||.||:|.||||:|||||||.|:::||.::||:.|||||:||||||||||
  Rat   390 GGAAAD-RGYFIQPTVFGDVKDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSKYGLAAAVFTK 453

  Fly   455 DLDKANYIVGGLRAGTVWVNTYNVLAAQAPFGGYKMSGHGRENGEYALSNYTEVKSVIVKVAQKN 519
            |||||||:...|:|||||:|.|:|..||:|||||||||.|||.|||.|..|||||:|.|||.|||
  Rat   454 DLDKANYLSQALQAGTVWINCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKN 518

  Fly   520 S 520
            |
  Rat   519 S 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	350/503 (70%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	345/480 (72%)
Aldh2	NP_115792.2	ALDH_F1AB_F2_RALDH1	33..513	CDD:143459	345/480 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353941
Domainoid	1	1.000	699	1.000	Domainoid score	I117
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55480
Inparanoid	1	1.050	737	1.000	Inparanoid score	I568
OMA	1	1.010	-	-		QHG53964
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	1	1.000	-	-		otm45781
orthoMCL	1	0.900	-	-		OOG6_100163
Panther	1	1.100	-	-	LDO	PTHR11699
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X158
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770