DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and Aldh5a1

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_074042.1	Gene:	Aldh5a1 / 291133	RGDID:	621422	Length:	523	Species:	Rattus norvegicus

Alignment Length:	522	Identity:	181/522 - (34%)
Similarity:	269/522 - (51%)	Gaps:	42/522 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GALLR----SQAKNFAAAVANYSSLPQPQTTPDILYTGVFINNEWHKSKSGKIFETINPTTAEVI 68
            |.|||    :|.:::....|:..:        |:|....|:...|..:.:  .|...:|.:...:
  Rat    21 GRLLREPAGAQRRSYVGGPADLHA--------DLLRGDSFVGGRWLPTPA--TFPVYDPASGAKL 75

  Fly    69 AEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDNGKP 133
            ..:......:...||:||.:||   |.|:.:...||..||.:..|||.:::..||.:.|.::|||
  Rat    76 GTVADCGVPEARAAVRAAYDAF---SSWKEISVKERSSLLRKWYDLMIQNKDELAKIITAESGKP 137

  Fly   134 YSMSYNVDLPTAIKNLRYFAGWADKNHGKTIPMDGDFFTYTR---------HEPVGVCGQIIPWN 189
            ...:....|.:|. .|.:|:..|.:.:|..|        ||.         .:||||...|.|||
  Rat   138 LKEAQGEILYSAF-FLEWFSEEARRVYGDII--------YTSAKDKRGLVLKQPVGVASIITPWN 193

  Fly   190 FPILMMAWKLGPALATGNTIVLKPAEQTSLTALYIAQLVKEAGFPEGVVNVVPGFGT----AGAA 250
            ||..|:..|:|.|||.|.|:|:||||.|..:||.:|||..:||.|.||.||:|...|    .|..
  Rat   194 FPSAMITRKVGAALAAGCTVVVKPAEDTPYSALALAQLANQAGIPPGVYNVIPCSRTKAKEVGEV 258

  Fly   251 LANHCDVDKVAFTGSTDVGKLIQLASGNTNLKRVTLELGGKSPNIILSDTDMDYAVETAHFGLFF 315
            |.....|.|::|||||..||::...:.| ::|||::||||.:|.|:....::|.||..|....|.
  Rat   259 LCTDPLVSKISFTGSTATGKILLHHAAN-SVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFR 322

  Fly   316 NMGQCCCAGSRTFVEDKIYDEFVERSAERAKKR-TVGNPFDLNTEQGPQVNEEQMEKILGMIKTG 379
            |.||.|...:|..|:..|:|.||.:.||..||. .|||.|:..|.|||.:||:.:||:...:...
  Rat   323 NAGQTCVCSNRFLVQRGIHDSFVTKFAEAMKKSLRVGNGFEEGTTQGPLINEKAVEKVEKHVNDA 387

  Fly   380 KKQGAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTIAREEIFGPVQQLIRFKKLDEVIERANNSE 444
            ..:||.:|.||.|.:. .|.|.:||:.::|..||....||.|||:..:|:|.|.:|.:..||.::
  Rat   388 VAKGATVVTGGKRHQS-GGNFFEPTLLSNVTRDMLCITEETFGPLAPVIKFDKEEEAVAIANAAD 451

  Fly   445 YGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLAAQAPFGGYKMSGHGRENGEYALSNYTEVK 509
            .|||...:::|..:...:...|..|.|.||...:.:.:.||||.|.||.|||..:|.:..|.|||
  Rat   452 VGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLEVK 516

  Fly   510 SV 511
            .|
  Rat   517 YV 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	180/521 (35%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	175/492 (36%)
Aldh5a1	NP_074042.1	SSADH	66..516	CDD:188167	167/463 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810