DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and Aldh1a7

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_036051.1	Gene:	Aldh1a7 / 26358	MGIID:	1347050	Length:	501	Species:	Mus musculus

Alignment Length:	495	Identity:	306/495 - (61%)
Similarity:	394/495 - (79%)	Gaps:	2/495 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SLPQPQTTPDILYTGVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFK 91
            ::|.|.....|.:|.:|||||||.|.|.|.|..:||.|.|||..::..||.|:|.||:|||.||:
Mouse     8 AVPAPLANLKIQHTKIFINNEWHDSVSSKKFPVLNPATEEVICHVEEGDKADVDKAVKAARQAFQ 72

  Fly    92 LGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWA 156
            :|||||.||||||||||.:||||||||::.||::|:::.||.::.:|.:|:..:||.|:||||||
Mouse    73 IGSPWRTMDASERGRLLNKLADLMERDRLLLATMESMNAGKVFAHAYLLDVEISIKALQYFAGWA 137

  Fly   157 DKNHGKTIPMDGDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTA 221
            ||.||:|||.||:.|||||.||:||||||||||.|:::..|||||||:.|||:|:||||||.|||
Mouse   138 DKIHGQTIPSDGNIFTYTRREPIGVCGQIIPWNGPLIIFTWKLGPALSCGNTVVVKPAEQTPLTA 202

  Fly   222 LYIAQLVKEAGFPEGVVNVVPGFG-TAGAALANHCDVDKVAFTGSTDVGKLIQLASGNTNLKRVT 285
            |::|.|:||||||.||||:|||:| |||.|:::|.|:|||:|||||:|||||:.|:|.:||||||
Mouse   203 LHMASLIKEAGFPPGVVNIVPGYGPTAGGAISSHMDIDKVSFTGSTEVGKLIKEAAGKSNLKRVT 267

  Fly   286 LELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTV 350
            ||||||||.|:.:|.|:|.|||.||.|:||:.||.|.|.||.|||:.||||||.||.|||||..:
Mouse   268 LELGGKSPCIVFADADLDSAVEFAHQGVFFHQGQICVAASRLFVEESIYDEFVRRSVERAKKYIL 332

  Fly   351 GNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTI 415
            |||.:....||||:::||..||||:|::|||:||||..||.| .|..|:|||||||::|.|:|.|
Mouse   333 GNPLNSGINQGPQIDKEQHNKILGLIESGKKEGAKLECGGGR-WGNKGFFVQPTVFSNVTDEMRI 396

  Fly   416 AREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLA 480
            |:|||||||||:::||.:|:||:||||:.|||||.|||||||||..:...|:||.||||.|..:.
Mouse   397 AKEEIFGPVQQIMKFKSMDDVIKRANNTTYGLAAGVFTKDLDKAITVSSALQAGMVWVNCYLAVP 461

  Fly   481 AQAPFGGYKMSGHGRENGEYALSNYTEVKSVIVKVAQKNS 520
            .|.||||:||||:|||.||:.|..|||:|:|.::::||||
Mouse   462 VQCPFGGFKMSGNGRELGEHGLYEYTELKTVAMQISQKNS 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	301/485 (62%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	300/480 (63%)
Aldh1a7	NP_036051.1	ALDH_F1AB_F2_RALDH1	15..494	CDD:143459	300/479 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53964
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100163
Panther	1	1.100	-	-	O	PTHR11699
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X158
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.830