DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and SPAC1002.12c

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_593499.2	Gene:	SPAC1002.12c / 2543267	PomBaseID:	SPAC1002.12c	Length:	547	Species:	Schizosaccharomyces pombe

Alignment Length:	527	Identity:	180/527 - (34%)
Similarity:	272/527 - (51%)	Gaps:	39/527 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ALLRSQAKN--FAAAVANYSSLPQPQTTPDILYTGVF----------INNEWHKSKSGKIFETIN 61
            :||:...:|  |||.::..|.|     :.:|....:|          |..:|..:.|||.|:..|
pombe    35 SLLKRNCRNRSFAANMSTSSKL-----STNIKDLSLFDLEEFPARSYIGGKWVTAASGKTFDVEN 94

  Fly    62 PTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLASLE 126
            |...|.:|.:.....|:...|::.|..||   ..:|..|..||..:|.|..||:..:...||::.
pombe    95 PGLNETLAPVTDMSVEETRKAIKVAHEAF---LSYRNSDIKERYAILRRWYDLIMENADDLATMM 156

  Fly   127 TLDNGKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTIPMDGDFF--------TYTRHEPVGVCG 183
            ||:|||.        |..|...:.|.|.:.|...|:.:.:.||..        ..|..:||||.|
pombe   157 TLENGKA--------LGDAKGEVVYAAKFIDWFAGEALRISGDSSMSSNPQNRIITIKQPVGVVG 213

  Fly   184 QIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTALYIAQLVKEAGFPEGVVNVVPGFGTA- 247
            .|.|||||..|:..|:|.|||.|.|:|::||.:|..|||.:|:|.:.||.|.||:|:|.....:
pombe   214 IITPWNFPAAMITRKVGAALAAGCTVVIRPAAETPFTALALAKLAERAGVPAGVLNMVTANSPSE 278

  Fly   248 -GAALANHCDVDKVAFTGSTDVGKLIQLASGNTNLKRVTLELGGKSPNIILSDTDMDYAVETAHF 311
             |..|..:..:.||:|||||:|||::...|.:| ||:::|||||.:|.|:..|.|::.|.:....
pombe   279 HGIELTTNPLIRKVSFTGSTNVGKILAKQSSST-LKKLSLELGGNAPFIVFEDADLEKAADALMA 342

  Fly   312 GLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVGNPFDLNTEQGPQVNEEQMEKILGMI 376
            ..|...||.|...:|.:|...:||.||:...||..|..:|...|.....||.::|:.:.|:...:
pombe   343 CKFRGSGQTCVCANRIYVHSSVYDAFVDLVTERVSKFKLGYGLDAGVTHGPLISEKAISKVKQHV 407

  Fly   377 KTGKKQGAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTIAREEIFGPVQQLIRFKKLDEVIERAN 441
            :...::|..:|.||.....|...:.:|||..:.:..|.|:.||.||||..|.:|...|||:..||
pombe   408 EDAVQKGGVVVTGGKVASNLGPMYFEPTVIINAKQGMLISEEETFGPVGALFKFDTEDEVVAWAN 472

  Fly   442 NSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLAAQAPFGGYKMSGHGRENGEYALSNYT 506
            :|..|||..:|:||:.:...:...|:.|.|..||..|....:||||.|.||.|||..:|.:|.|.
pombe   473 DSPVGLAGYLFSKDISRVFRVGEALQVGMVGCNTGLVSDVLSPFGGVKESGFGREGSKYGISEYL 537

  Fly   507 EVKSVIV 513
            ::||:.:
pombe   538 DIKSLTI 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	180/524 (34%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	172/500 (34%)
SPAC1002.12c	NP_593499.2	PLN02466	21..542	CDD:215259	179/523 (34%)
SPAC1002.12c	NP_593499.2	ALDH_F5_SSADH_GabD	92..544	CDD:143421	164/463 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810