DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and SPAC9E9.09c

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_594582.1	Gene:	SPAC9E9.09c / 2542976	PomBaseID:	SPAC9E9.09c	Length:	503	Species:	Schizosaccharomyces pombe

Alignment Length:	476	Identity:	249/476 - (52%)
Similarity:	341/476 - (71%)	Gaps:	3/476 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 GVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERG 105
            |:||||:...|..|...:..:|:|.::|.|:..||:||:||||:.||.||:..:|||:..:::||
pombe    24 GLFINNQHVDSVHGGRVKVYSPSTEKLICEVADADEEDVDIAVKVARAAFQTDAPWRKFSSAQRG 88

  Fly   106 RLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTIPMDGDF 170
            |.|.||||.:|::..||||:|||||||..:::.. |:..|....||:.|||||::|:||..|...
pombe    89 RCLSRLADCIEQNLEYLASIETLDNGKSITLARG-DVQAAADCFRYYGGWADKDYGQTIETDIKR 152

  Fly   171 FTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTALYIAQLVKEAGFPE 235
            |.||||||:||||||||||||.||.|||:.||:|.||||:||.||.|.|:||.:.:.|.|.|||.
pombe   153 FAYTRHEPIGVCGQIIPWNFPFLMCAWKIAPAVACGNTIILKTAELTPLSALCLTKFVPECGFPP 217

  Fly   236 GVVNVVPGFG-TAGAALANHCDVDKVAFTGSTDVGKLIQLASGNTNLKRVTLELGGKSPNIILSD 299
            ||:||:.|.| ..|.|:::|.|:|||||||||.||:::..|:.::|||:||||||||||||:.:|
pombe   218 GVINVLSGDGRRCGNAISSHMDIDKVAFTGSTGVGRMVMRAAASSNLKKVTLELGGKSPNIVFND 282

  Fly   300 TDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVGNPFDLNTEQGPQV 364
            .|:|.|....::|:|:|.||.||||||.:|::.:||||::|...:||...||:||..:|.||.||
pombe   283 ADLDSAAVWTNYGIFYNSGQVCCAGSRVYVQEDVYDEFIKRMVAKAKTLKVGDPFAEDTFQGAQV 347

  Fly   365 NEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTIAREEIFGPVQQLIR 429
            :::|.|:|:..|::|...||||..||.| .|..||||:||:.::|.:||.:.:|||||||..:|:
pombe   348 SKQQYERIVSYIESGIAHGAKLEIGGKR-HGNLGYFVEPTILSNVTEDMAVGKEEIFGPVLAVIK 411

  Fly   430 FKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLAAQAPFGGYKMSGHG 494
            ||.::|.|.|.|||.|||||.|.|.::..|..:...|.|||||||.||:|..|.||||||.||.|
pombe   412 FKTIEEAIRRGNNSTYGLAAGVHTNNITNAIKVSNALEAGTVWVNCYNLLHHQIPFGGYKESGIG 476

  Fly   495 RENGEYALSNYTEVKSVIVKV 515
            ||.|.|.|:|||:.|:|.:.:
pombe   477 RELGSYGLTNYTQTKAVHINL 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	248/471 (53%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	249/473 (53%)
SPAC9E9.09c	NP_594582.1	ALDH_AldA_AN0554	17..497	CDD:143461	249/474 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	495	1.000	Domainoid score	I58
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55480
Inparanoid	1	1.050	509	1.000	Inparanoid score	I235
OMA	1	1.010	-	-		QHG53964
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	1	1.000	-	-		otm47084
orthoMCL	1	0.900	-	-		OOG6_100163
Panther	1	1.100	-	-	LDO	PTHR11699
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2025
SonicParanoid	1	1.000	-	-		X158
TreeFam	0	0.000	Not matched by this tool.
	13	12.900