DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and SPBC24C6.04

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001342759.1	Gene:	SPBC24C6.04 / 2540387	PomBaseID:	SPBC24C6.04	Length:	548	Species:	Schizosaccharomyces pombe

Alignment Length:	525	Identity:	128/525 - (24%)
Similarity:	221/525 - (42%)	Gaps:	78/525 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 PQTTPDILYTGVFINNEWHKSKSGKIFETINPTTAE---------VIAEIQCADKEDIDIAVQAA 86
            |.|.|.|:              .||..||  .|..|         |:|....|..:.::.|::||
pombe    42 PVTIPVII--------------DGKEVET--NTIGEQRCPFEHKKVVARYHRAGAKHVEDAIEAA 90

  Fly    87 RNAFKLGSPWRRMDASERGRLLYRLADLMERDQVY-LASLETLDNGKPYSMSYNVDLPTAIKN-L 149
            ....|:   |..:..::|..:..:.|.|:.....| |.:...:..||....: .:|....|.: |
pombe    91 LRGKKV---WESLPFADRSAIFLKAAHLISTKYRYKLMAATMIGQGKNIWQA-EIDAGMEIIDFL 151

  Fly   150 RYFAGWADK--------------NHGKTIPMDGDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLG 200
            |:...:|.:              |..:..|::|  |.|.          |.|:||..:  |..|.
pombe   152 RFNTKYASELYASQPPENTPGVWNRMEYRPLEG--FVYA----------ITPFNFTAI--AGNLA 202

  Fly   201 PA-LATGNTIVLKPAEQTSLTALYIAQLVKEAGFPEGVVNVVPGFGTAGAALA-NHCDVDKVAFT 263
            .| |..||.:::||::...|::..:.|:.:|||.|.|.:..:||.....:.:. ||.:...:.||
pombe   203 AAPLLMGNVVLMKPSDHAVLSSYIVYQIFREAGLPAGALQFIPGDAVEVSKVCFNHPEFAGLHFT 267

  Fly   264 GSTDVGKLI------QLASGN-TNLKRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCC 321
            |||.|.:.:      .:|:|. ....::..|.|||:.:::.|..::..||..|....|...||.|
pombe   268 GSTAVFRSLWGTIGENVANGKYRTYPKIVGETGGKNFHLVHSSAEIKSAVVNAVRAAFEYQGQKC 332

  Fly   322 CAGSRTFVEDKIYDE-FVERSAERAKKRTVGNPF-DLNTEQGPQVNEEQMEKILGMIKTGKKQGA 384
            .|.||.:|....::. |.:...::.|...||.|. |.....||.:::....|:..::::......
pombe   333 SALSRLYVSKYAWENGFRDELTKQVKSLKVGAPLTDFANFVGPVIHQASFNKLKKVLESAASDSE 397

  Fly   385 KLVAGGSRPEGLPGYFVQPTVFADVQDDMTIAREEIFGPVQQLIRFK--KLDEVIERAN-NSEYG 446
            ..|..|.:.:...|:||:|||.........|...|:||||..:..::  .||.|.:..: .:.||
pombe   398 IEVLAGGKADDSEGFFVEPTVLLSKNPKHDIFVNELFGPVLSVYVYEDDNLDAVCDLIDTTTPYG 462

  Fly   447 LAAAVFTKDLDKANYIVGGLR--AGTVWVN--TYNVLAAQAPFGGYKMSGHGRENGE-YALSNYT 506
            |..::|.:|......:...||  ||..::|  ....:..:.||||.:.||...:.|. ..||.:.
pombe   463 LTGSIFAQDRVVVRKLTDRLRNAAGNFYINDKCTGAVVGEQPFGGARASGTNDKAGSGMILSRFV 527

  Fly   507 EVKSV 511
            ..:|:
pombe   528 SPRSI 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	128/525 (24%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	126/522 (24%)
SPBC24C6.04	NP_001342759.1	ALDH_F4-17_P5CDH	12..537	CDD:143441	128/525 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810