DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and Aldh1a1

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_038949786.1	Gene:	Aldh1a1 / 24188	RGDID:	2087	Length:	520	Species:	Rattus norvegicus

Alignment Length:	495	Identity:	311/495 - (62%)
Similarity:	396/495 - (80%)	Gaps:	2/495 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SLPQPQTTPDILYTGVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFK 91
            ::|.|.....|.:|.:|||||||.|.|||.|..:||.|.|||..::..||.|:|.||:|||.||:
  Rat    27 AVPAPLANLKIQHTKIFINNEWHDSVSGKKFPVLNPATEEVICHVEEGDKADVDKAVKAARQAFQ 91

  Fly    92 LGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWA 156
            :|||||.||||||||||.:||||||||::.||::|.::.||.::.:|..||..:||.|:|.||||
  Rat    92 IGSPWRTMDASERGRLLNKLADLMERDRLLLATIEAINGGKVFANAYLSDLGGSIKALKYCAGWA 156

  Fly   157 DKNHGKTIPMDGDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTA 221
            ||.||:|||.|||.||:||.||:||||||||||||:||..||:||||:.|||:|:||||||.|||
  Rat   157 DKIHGQTIPSDGDIFTFTRREPIGVCGQIIPWNFPLLMFIWKIGPALSCGNTVVVKPAEQTPLTA 221

  Fly   222 LYIAQLVKEAGFPEGVVNVVPGFG-TAGAALANHCDVDKVAFTGSTDVGKLIQLASGNTNLKRVT 285
            |::|.|:||||||.||||:|||:| |||||:::|.|||||||||||.|||||:.|:|.:||||||
  Rat   222 LHMASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDVDKVAFTGSTQVGKLIKEAAGKSNLKRVT 286

  Fly   286 LELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTV 350
            ||||||||.|:.:|.|:|.|||.||.|:|::.||||.|.||.|||:.:|||||.:|.|||||..:
  Rat   287 LELGGKSPCIVFADADLDIAVEFAHHGVFYHQGQCCVAASRIFVEESVYDEFVRKSVERAKKYVL 351

  Fly   351 GNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTI 415
            |||......||||:::||.:|||.:|::|||:||||..||.| .|..|:|||||||::|.|:|.|
  Rat   352 GNPLTQGINQGPQIDKEQHDKILDLIESGKKEGAKLECGGGR-WGNKGFFVQPTVFSNVTDEMRI 415

  Fly   416 AREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLA 480
            |:|||||||||:::||.:|:||:||||:.|||||.|||||||:|..:...|:||.||||.|.:|:
  Rat   416 AKEEIFGPVQQIMKFKSIDDVIKRANNTTYGLAAGVFTKDLDRAITVSSALQAGVVWVNCYMILS 480

  Fly   481 AQAPFGGYKMSGHGRENGEYALSNYTEVKSVIVKVAQKNS 520
            ||.||||:||||:|||.||:.|..|||:|:|.:|::||||
  Rat   481 AQCPFGGFKMSGNGRELGEHGLYEYTELKTVAMKISQKNS 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	305/485 (63%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	304/480 (63%)
Aldh1a1	XP_038949786.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	304/480 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53964
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100163
Panther	1	1.100	-	-	O	PTHR11699
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X158
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.830