Protein Alignment Aldh and Aldh8a1

DIOPT Version :9

• Sequence 1: NP_001260290.1
• Gene: Aldh / 34256
• FlyBaseID: FBgn0012036
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_848828.1
• Gene: Aldh8a1 / 237320
• MGIID: 2653900
• Length: 487
• Species: Mus musculus
• Alignment Length: 491
• Identity: 176/491 - (35%)
• Similarity: 280/491 - (57%)
• Gaps: 22/491 - (4%)

  Fly    36 DILYTGVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMD 100
            ::|....||..::....|  ..::.:|:|.||..::..:.||:|:.||:|||.||   ..|....
Mouse     6 ELLMLENFIGGKFLPCNS--YIDSYDPSTGEVYCKVPNSGKEEIEAAVEAAREAF---PAWSSRS 65

  Fly   101 ASERGRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTIP 165
            ..||..:|.||||::|:....||..|:.|.||..:::..:|:|.::.|.|:||. ::.:|.....
Mouse    66 PQERSLVLNRLADVLEQSLEELAQAESKDQGKTLTLARTMDIPRSVLNFRFFAS-SNLHHVSECT 129

  Fly   166 MDGDF--FTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTALYIAQLV 228
            .....  ..||...|||:.|.|.|||.|:.::.||:.||:|.|||::.||:|.||:||....:|:
Mouse   130 QMSHLGCMHYTVRTPVGIAGLISPWNLPLYLLTWKIAPAIAAGNTVIAKPSEMTSVTAWMFCKLL 194

  Fly   229 KEAGFPEGVVNVVPGFGT---AGAALANHCDVDKVAFTGSTDVG-KLIQLASGNTNLKRVTLELG 289
            .:||.|.||:|:|  |||   .|.||.:|.:|..::||||.... ::.||::  .:.|:::||||
Mouse   195 DKAGVPPGVINIV--FGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA--PHCKKLSLELG 255

  Fly   290 GKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVGNPF 354
            ||:|.||..|.:::..:.......|.|.|:.|...||.||:..||.||::|..|..:|..||.|.
Mouse   256 GKNPAIIFEDANLEECIPATVRSSFANQGEICLCTSRIFVQRSIYSEFLKRFVEATRKWKVGVPS 320

  Fly   355 DLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAG-GSRPEGLP-----GYFVQPTVFADVQDDM 413
            |.:...|..:::..:||:...:...:.:||:::.| |.....||     |||:.|||..|::|:.
Mouse   321 DPSANMGALISKAHLEKVRSYVLKAQTEGARILCGEGVDQLSLPLRNQAGYFMLPTVITDIKDES 385

  Fly   414 TIAREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNV 478
            ....|||||||..::.|...:|||.|||:..|||||.|::||:.:.:.:...|::|.||.|.:.:
Mouse   386 RCMTEEIFGPVTCVVPFDSEEEVITRANSVRYGLAATVWSKDVGRIHRVAKKLQSGLVWTNCWLI 450

  Fly   479 LAAQAPFGGYKMSGHGRENGEYALSNYTEVKSVIVK 514
            .....||||.|.||.|||..:.:...:||:|::.:|
Mouse   451 RELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITIK 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	175/487 (36%)
		ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	175/489 (36%)
Aldh8a1	NP_848828.1	ALDH_F8_HMSADH	27..485	CDD:143412	171/465 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810