Protein Alignment Aldh and ALDH3A2

DIOPT Version :9

• Sequence 1: NP_001260290.1
• Gene: Aldh / 34256
• FlyBaseID: FBgn0012036
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_001026976.1
• Gene: ALDH3A2 / 224
• HGNCID: 403
• Length: 508
• Species: Homo sapiens
• Alignment Length: 465
• Identity: 123/465 - (26%)
• Similarity: 209/465 - (44%)
• Gaps: 66/465 - (14%)

  Fly    79 IDIAVQAARNAFKLGSPWRRMDASERGR-LLYRLADL-------MERDQVYLASLETLDNGKPYS 135
            :::.|:..|.||..|          |.| |.:||..|       .||::..|.:: ..|..|...
Human     1 MELEVRRVRQAFLSG----------RSRPLRFRLQQLEALRRMVQEREKDILTAI-AADLCKSEF 54

  Fly   136 MSYNVDLPTAIKNLRY----FAGWADKNHGKTIPMDGDFFT-----YTRHEPVGVCGQIIPWNFP 191
            ..|:.::.|.:..:.:    ...|....     |:..:..|     |.:.:|:||...|..||:|
Human    55 NVYSQEVITVLGEIDFMLENLPEWVTAK-----PVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYP 114

  Fly   192 ILMMAWKLGPALATGNTIVLKPAEQTSLTALYIAQLVKEAGFPEGVVNVVPGFGTAGAALANHCD 256
            .::....|..|:|.||.:::||:|.:..||..:|:|:.:  :.:..:.:|...|...........
Human   115 FVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQ--YLDQDLYIVINGGVEETTELLKQR 177

  Fly   257 VDKVAFTGSTDVGKLIQLASGNTNLKRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCC 321
            .|.:.:||:|.|||::..|:.. :|..||||||||||..|..|.|:|.......:|.:.|.||.|
Human   178 FDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTC 241

  Fly   322 CAGSRTFVEDKIYDEFVERSAERAKKRTVGNPFDLNTEQGPQ----VNEEQMEKILGMIKTGKKQ 382
            .|......|..:.::.|.:.     |.||...:..|.::.|.    :|....::||.::     :
Human   242 IAPDYILCEASLQNQIVWKI-----KETVKEFYGENIKESPDYERIINLRHFKRILSLL-----E 296

  Fly   383 GAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTIAREEIFGPVQQLIRFKKLDEVIERANNSEYGL 447
            |.|:..||...|..  .::.|||..||.....:.:||||||:..::..|.:||.|...|..|..|
Human   297 GQKIAFGGETDEAT--RYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPL 359

  Fly   448 AAAVFTKD-------LDKANYIVGGLRAGTVWVN-TYNVLAAQAPFGGYKMSGHGRENGEYALSN 504
            |..||:.:       :|:.:  .||:....|.:: |.|    ..||||...||.|..:|:::...
Human   360 ALYVFSHNHKLIKRMIDETS--SGGVTGNDVIMHFTLN----SFPFGGVGSSGMGAYHGKHSFDT 418

  Fly   505 YTEVKSVIVK 514
            ::..:..::|
Human   419 FSHQRPCLLK 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	122/461 (26%)
		ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	122/463 (26%)
ALDH3A2	NP_001026976.1	ALDH_F3AB	5..444	CDD:143450	123/461 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810